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Dinaciclib (SCH 727965) is a potent and selective CDK inhibitor and a novel cytotoxic agent. It inhibits CDK2, CDK5, CDK1, and CDK9 activity in vitro with IC50 values of 1, 1, 3, and 4 nM, respectively. It exhibits superior activity, compared with flavopiridol, with a much improved therapeutic index. It is currently in clinical trials.
Catalog NO: CT-DINA
Synonym: SCH 727965, SCH727965
CAS NO: 779353-01-4
Mol. Formula: C21H28N6O2 ∙ 1/2 H2O
MW: 405.5
** in vivo Grade Material, >99.5% by achiral and chiral HPLCs. A recrystallized beige powder (pic attached), clean & impeccable 1H-NMR, Hemihydrate, validated by a spot-on Quantitative Elemental Analysis. Bulk stock. Prompt.