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S63845 (S-63845)
S63845 is the first high affinity MCL-1 inhibitor with in vivo activity, binding to the BH3 groove of human MCL-1 with a KD value of 0.19 nM, highly selective against other BCL family proteins BCL-2 (Ki >10,000nM) and BCL-XL (Ki >10,000nM) (ref 1). S63845 showed the clear-on-target activity killing Mcl-1-dependent cancer cells, including multiple myeloma, leukemia and lymphoma cells. Demonstrated potent in vivo antitumor activity, with an acceptable safety margin, as a single agent in several cancer types (ref 1).
Catalog NO: CT-S63845
Synonym: S-63845
CAS NO: 1799633-27-4
Mol. Formula: C39H37ClF4N6O6S∙H2O
MW: 847.3
** 99.9-100% pure, in vivo grade material. A single isomer (ref. 2a) (out of possible four), off-white (All original QC Docs attached), with a spot-on microanalysis and validated potency (IC50 < 1nM) (ref. 2b). Bulk (get quote)! Same day shipping.