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Home > Kinase Inhibitors > BTK (Bruton's Tyrosine Kinase) > Pirtobrutinib

Pirtobrutinib

Pirtobrutinib (LOXO-305) is an orally active highly selective non-covalent Bruton’s tyrosine kinase (BTK) inhibitor. It inhibits wild-type and mutant BTK (IC₅₀s = 10-100 and <10 nM for wild-type BTK and BTK^481S, respectively). Pirtobrutinib is more than 300-fold selective for BTK over 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models.

Catalog NO:	CT-LOXO305
Synonym:	LOXO-305
CAS NO:	2101700-15-4
Mol. Formula:	C22H21F4N5O3
MW:	479.4 (or refer to the Certificate of Analysis, batch-specific)

** in vivo Quality Material. >99% Pure by Achiral and Chiral HPLCs (attached). Anhydrous, verified by a spot-on Elemental Analysis. Bulk stock (Discounted price for 0.2, 0.5, 1G, …). Same Day Shipping.

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NO	Size	Price	In Stock	Quantity
1	10 mg	$100.00	YES
2	50 mg	$300.00	YES
3	100 mg	$450.00	YES

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : >99% by Achiral and Chiral HPLCs

Original QC Data : Achiral and Chiral HPLCs, NMR, and Quantitative Elemental Analysis Report

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Pirtobrutinib (LOXO-305) Lot 01 Certificate of Analysis.pdf
Pirtobrutinib (Loxo-305) Lot 01 Visual Appearance.pdf
C_K, LOXO-305 Lot 01 Achiral HPLC.pdf
C_K, LOXO-305 Lot 01 Chiral HPLC.pdf
C_K, LOXO-305 Lot 01 NMR.pdf

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