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Skip Navigation LinksHome > Cell Cycle/Apoptosis Modulators > p53-MDM2 Interaction Inhibitor > NVP-HDM201 (Siremadlin) (HDM-201)
NVP-HDM201 (Siremadlin) (HDM-201)
NVP-HDM201 (Siremadlin) (HDM201) is an orally bioavailable, potent and selective inhibitor of p53-MDM2 interaction, binding to human MDM2 protein with a picomolar Ki value (0.21 nM). Highly selective against MDM4 protein (Ki = 3300 nM, >10000 fold selectivity). It activates p53 and induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells. Its activity and selectivity have been tested and confirmed in both in vitro and in vivo. Application of NVP-HDM201 using various dosing schedules triggers rapid and sustained activation of p53-dependent pharmacodynamics biomarkers resulting in tumor regression in multiple xenorgrafted models of p53 wild-type human cancers. It is currently in clinical development.
Catalog NO: CT-HDM201
Synonym: Siremadlin, HDM201, HDM-201
CAS NO: 1448867-41-1
Mol. Formula: C26H24Cl2N6O4
MW: 555.4 (or refer to Certificate of Analysis, batch specific)
** in vivo grade material. White powder (picture attached). 99.5-100% purity by achiral and chiral HPLCs. Hemihydrate, validated by a spot-on elemental analysis. Bulk stock (get discounted quote for larger qty)! Same day shipping.