LY2835219 (Abemaciclib) (Free Base) - Chemietek

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Home > Kinase Inhibitors > CDK (Cyclin-dependent Kinase) > LY2835219 (Abemaciclib) (Free Base)

LY2835219 (Abemaciclib) (Free Base)

LY2835219 (Abemaciclib) is an orally available cyclin-dependent kinase (CDK) inhibitor targeting specifically the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway. It blocks retinoblastoma (Rb) protein phosphorylation in early G1 thus prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. It is currently in clinical evaluation for cancer treatment.

Catalog NO:	CT-LY283
Synonym:	Abemaciclib
CAS NO:	1231929-97-7 (Free Base)
Mol. Formula:	C27H32F2N8 ∙ 0.4H2O
MW:	513.9 (refer to Certificate of Analysis, batch-specific)

** in vivo Quality Material. >99% Pure. Free Base, Hemihydrate, validated by a Quantitative Elemental Analysis. Bulk Stock!! Prompt.

Pricing and OrderingTechnical Data

QC & Certificates

References

NO	Size	Price	In Stock	Quantity
1	50 mg	$100.00	YES
2	200 mg	$260.00	YES
3	500 mg	$480.00	YES

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Solubility : Refer to Certificate

Storage : Refer to Certificate

Purity : 99.5% by HPLC

Original QC Data : HPLC-MS, 1H-NMR, and Quantitative Elemental Analysis Report

Please Pick Batch NO:

LY-2835219, Lot 04, Certificate of Analysis.pdf
LY-2835219, Lot 04, Visual Appearance.pdf
C_K, LY2835219, Lot 04, HPLC, 220nm.pdf
C_K, LY2835219, Lot 04, NMR,.pdf

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