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Skip Navigation LinksHome > Kinase Inhibitors > CDK (Cyclin-dependent Kinase) > LY2835219 (Abemaciclib) (Free Base)
LY2835219 (Abemaciclib) (Free Base)
LY2835219 (Abemaciclib) is an orally available cyclin-dependent kinase (CDK) inhibitor targeting specifically the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway. It blocks retinoblastoma (Rb) protein phosphorylation in early G1 thus prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. It is currently in clinical evaluation for cancer treatment.
Catalog NO: CT-LY283
Synonym: Abemaciclib
CAS NO: 1231929-97-7 (Free Base); 1231930-82-7 (Mesylate Salt)
Mol. Formula: C27H32F2N8 ∙ 0.4H2O
MW: 513.9 (refer to Certificate of Analysis, batch-specific)