INCB018424 (Ruxolitinib) - Chemietek

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Home > Kinase Inhibitors > JAK1/JAK2 Selective > INCB018424 (Ruxolitinib)

INCB018424 (Ruxolitinib)

INCB018424 (Ruxolitinib) is a potent, selective and orally bioavailable inhibitor of JAK1 (Ki 2.7 nM) and JAK2 (Ki 4.5 nM). Inhibit JAK3 at Ki 343 nM. Over 100 fold selectivity against a broad panel of other kinases.

Catalog NO:	CT-INCB
Synonym:	Ruxolitinib, INCB18424, INCB-18424
CAS NO:	941678-49-5
Mol. Formula:	C₁₇H₁₈N₆
MW:	306.4

** in vivo Quality Material. >99% by Achiral and Chiral HPLCs. Anhydrous, validated with high-precision quantitative elemental analysis. Bulk stock, prompt.

Pricing and OrderingTechnical Data

QC & Certificates

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NO	Size	Price	In Stock	Quantity
1	10 mg	$70.00	YES
2	50 mg	$120.00	YES
3	100 mg	$180.00	YES
4	200 mg	$300.00	YES
5	500 mg	$600.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0 °C (short term), -20 °C (long term), desiccated

Purity : Refer to Certificate of Analysis, batch-specific

Original QC Data : HPLC, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis

Please Pick Batch NO:

INCB018424, Lot 19, Certificate of Analysis.pdf
INCB018424, Lot 19, Appearance.pdf

1. R. A. Mesa, Ruxolitinib, a selective JAK1 and JAK2 inhibitor for the treatment of myeloproliferative neoplasms and psoriasis. IDrugs, 2010, 13(6), 394-403

2. C Campas-Moya. Ruxolitinib. Drugs Fut. 2010, 35(6), 457

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