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Home > Kinase Inhibitors > Syk (Spleen Tyrosine Kinase) > GS-9973 (Entospletinib)

GS-9973 (Entospletinib)

Spleen tyrosine kinase (Syk), a non-receptor cytoplasmic, BCR-associated enzyme, is expressed in hematopoietic tissues and is often overexpressed in hematopoeitic malignancies. GS-9973 (Entospletinib) is a highly selective and orally efficacious inhibitor of spleen tyrosine kinase (Syk) with an IC50 of 7.7 nM. It inhibits the activity of Syk, which inhibits B-cell receptor (BCR) signaling and leads to an inhibition of tumor cell activation, migration, adhesion and proliferation. It is currently in clinical evaluation for autoimmune and oncology indications.

Catalog NO:	CT-GS9973
Synonym:	Entospletinib
CAS NO:	1229208-44-9
Mol. Formula:	C₂₃H₂₁N₇O
MW:	411.5

** A recrystallized crystalline powder/flakes (see attached picture), clean (>99% by HPLC), + impeccable 1H-NMR, coming with a perfect Quantitative Elemental Analysis. Bulk in stock. Ship within 1 day.

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	10 mg	$80.00	YES
2	50 mg	$160.00	YES
3	100 mg	$260.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99% Purity (HPLC, detected at 214 and 254 nm)

Original QC Data : HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis

Please Pick Batch NO:

GS-9973, Curent Lot, Certificate of Analysis
GS-9973, Current Lot, NMR
GS-9973, Current Lot, HPLC-MS
GS-9773, Lot 01, Appearance (color).pdf

1. K. S. Currie, et al., Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase, J. Med. Chem., April 6, 2014

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