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Skip Navigation LinksHome > Kinase Inhibitors > Syk (Spleen Tyrosine Kinase) > GS-9973 (Entospletinib)
GS-9973 (Entospletinib)
Spleen tyrosine kinase (Syk), a non-receptor cytoplasmic, BCR-associated enzyme, is expressed in hematopoietic tissues and is often overexpressed in hematopoeitic malignancies. GS-9973 (Entospletinib) is a highly selective and orally efficacious inhibitor of spleen tyrosine kinase (Syk) with an IC50 of 7.7 nM. It inhibits the activity of Syk, which inhibits B-cell receptor (BCR) signaling and leads to an inhibition of tumor cell activation, migration, adhesion and proliferation. It is currently in clinical evaluation for autoimmune and oncology indications.
Catalog NO: CT-GS9973
Synonym: Entospletinib
CAS NO: 1229208-44-9
Mol. Formula: C23H21N7O
MW: 411.5
** A recrystallized crystalline powder/flakes (see attached picture), clean (>99% by HPLC), + impeccable 1H-NMR, coming with a perfect Quantitative Elemental Analysis. Bulk in stock. Ship within 1 day.