GS-9973 (Entospletinib) - Chemietek

Welcome visitor Log In - or - Register

(

0 items /

$0.00

)

View Cart

four ways

Home

New Products (II)

New & Featured Products

Kinase Inhibitors

Expand Kinase Inhibitors

Activated Factor VII (Factor VIIa)

Expand Activated Factor VII (Factor VIIa)

Arginase Inhibitor

Adenosine Receptor Ligands

Autotaxin Inhibitor

Bcl-2 Protein Inhibitors/Degraders

Expand Bcl-2 Protein Inhibitors/Degraders

BCL-6 Protein Inhibitors

CD73 Immune Pathway Inhibitor/Modulator

Expand CD73 Immune Pathway Inhibitor/Modulator

Cell Cycle Modulators

Expand Cell Cycle Modulators

Cell Metabolism Modulators

Expand Cell Metabolism Modulators

Expand Chemotherapy

CoREST-selective Deacetylase (CoreDAC) inhibitors

Degraders (Protein Degraders)

DNA Methyltransferase Inhibtors

DNA Repair Targeted Therapy

DNA/RNA Synthesis Inhibitor/Blocker

Endoplasmic Reticulum Stress Modulator (ERSM)

Epigenetics Resch Products

Expand Epigenetics Resch Products

Estrogen Receptor Modulators

Gamma (γ) Secretase (GS) Inhibitors

Glucocorticoid Receptor Antagonist/Modulator

Glucokinase Activator

Glutaminase Inhibitor

G-Protein-coupled Receptor Ligands

Expand G-Protein-coupled Receptor Ligands

Heat Shock Protein Research Products

Expand Heat Shock Protein Research Products

Hedgehog Signaling Pathway Modulators

Expand Hedgehog Signaling Pathway Modulators

Hippo Pathway Signaling Inhibitor

HMG-CoA Reductase

Expand HMG-CoA Reductase

Hormone Receptor Modulators

Expand Hormone Receptor Modulators

Hydrolase Inhibitors/Modulators

Expand Hydrolase Inhibitors/Modulators

IDO1 (INDOLEAMINE 2,3-DIOXYGENASE 1) Inhibitors

IDH (Isocitrate Dehydrogenase) Inhibitors

Expand IDH (Isocitrate Dehydrogenase) Inhibitors

IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor

Expand IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor

Immune Activation Agents/Modulators

Expand Immune Activation Agents/Modulators

Immuno/Inflammatory Mediators

Expand Immuno/Inflammatory Mediators

Immunoproteasome Inhibitor

Immuno-oncology Modulators

Expand Immuno-oncology Modulators

Immunosuppressants/Immunochemotherapy Agents

Isomerase Inhibitor/Modulator

Expand Isomerase Inhibitor/Modulator

Kinesin Ligand/Modulator

Expand Kinesin Ligand/Modulator

KRAS Pathway Inhibitors

Expand KRAS Pathway Inhibitors

Liver X receptor (LXR) Agonist/Modulator

Metabolic Pathway Modulators

Expand Metabolic Pathway Modulators

Monocarboxylate Transporter 1 (MCT 1) Inhibitor/Ligand

Expand Monocarboxylate Transporter 1 (MCT 1) Inhibitor/Ligand

Monocarboxylate Transporter 4 (MCT 4) Inhibitor

MTH1 (NUDT1, Human MutT Homologue)

Expand MTH1 (NUDT1, Human MutT Homologue)

Neuroactive Research Products

Expand Neuroactive Research Products

Notch/Wnt Signaling Pathway

Expand Notch/Wnt Signaling Pathway

Nuclear Export Protein Inhibitors/Modulators

Expand Nuclear Export Protein Inhibitors/Modulators

Other Enzyme Inhibitors/Modulators

Expand Other Enzyme Inhibitors/Modulators

OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator

PD-1/PD-L1 Checkpoint Inhibitors

p53–MDM2 Modulators

Expand p53–MDM2 Modulators

PCNA (Proliferating Cell Nuclear Antigen)

PDE4 ( Phosphodiesterase Type 4) Inhibitor/Modulators

Phosphatase Inhibitors/Modulators

Expand Phosphatase Inhibitors/Modulators

PLA2 (Phospholipase A2) Inhibitor

Polymerase Inhibitor/Modulator

Expand Polymerase Inhibitor/Modulator

PPARG Agonist (Peroxisome Proliferator-activated Receptor Gamma Agomist)

Reagents for Biological Assays

RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist

SMAC Mimics and Inhibitors of IAP

Stem Cell Research Products

Expand Stem Cell Research Products

STING (Stimulator of Interferon Genes) Agonist

SUMO Pathway Modulator

Toll-like Receptor Modulators

Ubiquitin / Proteasome System

Expand Ubiquitin / Proteasome System

Wnt Signaling Pathway Modulators

WRN helicase Inhibitor

YAP/TAZ Signaling Inhibitor

Zinc Finger Protein Degrader

Scroll up

Scroll down

Akt/(PKB (Protein Kinase B)

ALK (Anaplastic Lymphoma Kinase)

AMPK (AMP-Activated Protein Kinase)

ASK1 (Apoptosis Signal-regulating Kinase 1)

ATM (Ataxia Telangiectasia Mutated Kinase)

ATR (Ataxia Telangiectasia and Rad3 Related)

Aurora A Kinase Selective

Aurora B Kinase Selective

Aurora C Kinase Selective

AXL (AXL Receptor Tyrosine Kinase)

Bcr-Abl/c-kit/PDGFR/Src

BTK (Bruton's Tyrosine Kinase)

BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)

CDC7 (Cell Division Cycle 7-related Protein Kinase)

CDK (Cyclin-dependent Kinase)

CHK (Checkpoint Kinase)

CLK (CDC2-like-Kinase)

CLK2 (CDC2-like Kinase 2)

DDK (Dbf4-dependent kinase)

DNA-PK (DNA-Dependent Protein Kinase)

EphB4 (Ephrin Type-B Receptor 4) Kinase

Erk (Extracellular signal regulated kinase)

FAK (Focal Adhesion Kinase)

FGFR (Fibroblast Growth Factor Receptor)

FLT3 (Fms-like Tyrosine Kinase 3)

JAK (Janus Kinase)

JAK1/JAK2 Selective

Mps1 (Monopolar Spindle 1)

NIK (NF-κB-inducing kinase) Inhibitors

P21-Activated Kinases

P70S6K (Ribosomal Protein S6 Kinase)

PI3K - p110 Alpha (α) Specific

PI3K - p110 Beta (β) Specific

PI3K - p110 Delta (δ) Specific

PI3K - p110 Gamma (γ) Specific

PKC (Protein Kinase C)

PLK (Polo-like kinase)

PLK1 (Polo-like Kinase 1) Selective

PLK4 (Polo-like Kinase 4) Selective

RAF (Rapidly Accelerated Fibrosarcoma)

RET (Rearranged During Transfection) Kinase

RIP1 (Receptor Interacting Protein 1) Kinase

ROCK (Rho-Associated Protein Kinase)

ROS1 (Proto-oncogene Tyrosine-protein Kinase ROS)

Syk (Spleen Tyrosine Kinase)

TGFβ (Transforming Growth Factor Beta (TGFβ) Receptor) Kinase

TOPK (T–lymphokine-activated killer cell–originated protein kinase)

TRK (Tropomyosin Receptor Kinase) (Tyrosine Receptor Kinase)

TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))

Scroll up

Scroll down

Factor VIIa inhibitor

Scroll up

Scroll down

Bcl-2 Family Protein Inhibitors

BCL-2 Selective Inhibitors

BCL-XL Protein Degrader

BCL-XL Selective Inhibitors

MCL-1 Selective Inhibitors

Scroll up

Scroll down

CD73 (ecto-5'-nucleotidase) Inhibitor

Scroll up

Scroll down

BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)

CBP/β-catenin Modulators

Cell Cycle/DNA Damage

CDK Inhibitors/Modulators

CDC7 (Cell Division Cycle 7-related Protein Kinase)

CHK (Checkpoint Kinase)

CLK (CDC2-like-Kinase)

DNA Replication Modulators/Breakers

Endoplasmic Reticulum Stress Modulator (ERSM)

G-Quadruplex Ligand

IMPDH Inhibitor

Kinesin (CENP-E) Inhibitor

KRAS-G12C Inhibitors

KRASG12C (ON) (Tri-complex) Inhibitor

KRAS-G12D Inhibitors

KRAS-PDEδ Interaction Inhibitor

KRAS-SOS1 Inhibitors

Menin-KMT2A/MLL interaction inhibitors

Mps1 (Monopolar Spindle 1)

Notch Signaling Inhibitors

OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor

p53-MDM2 Interaction Inhibitor

PCNA (Proliferating Cell Nuclear Antigen)

PRC2 (the catalytic subunit of polycomb repressive complex 2) >

PKMYT1 Kinase Inhibitor

SMAC Mimics and Inhibitors of IAP

TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))

Scroll up

Scroll down

Monocarboxylate Transporter 1 (MCT 1) Inhibitor

Mutant Isocitrate Dehydrogenase-1 (IDH1) Inhibitor

Mutant Isocitrate Dehydrogenase-2 (IDH2) Inhibitor

OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor

Scroll up

Scroll down

Chemotherapy Agents

Scroll up

Scroll down

ATPases (BRG1/BRM)

BET Family Protein Degraders

BET Family Protein Inhibitors

BET/Bromodomain (BDI and BDII) Selective Inhibitors

BET/BRD4 Degrader

BET/BRD9 Degrader

BET Bromodomain II (BDII) Selective Inhibitors

BET/Domain & Sub-set Selective Inhibitors

CBP/P300 Bromodomain Inhibitor

CoreDAC Inhibitors

DNMT1 (DNA Methyltransferase 1) inhibitor

DOT1L Methyltransferase Inhibitor

EP300/CBP HAT (Histone Acetyltransferases) Inhibitor

EZH1/2 Dual Inhibitors

EZH2 Methyltransferase Inhibitors

EZH2 (Mutant) METHYLTRANSFERASE INHIBITOR

HDAC (histone deacetylase) Inhibitors

HDAC1-Specific Inhibitors

HDAC3-Specific Inhibitors

HDAC6-Specific Inhibitors

Lysine specific demethylase 1 (LSD1) Inhibitor

Menin-KMT2A/MLL interaction inhibitors

PRC2 (the catalytic subunit of polycomb repressive complex 2)

PRMT5 (Protein Arginine Methyltransferase 5) Inhibitors/Modulators

PRMTs (Type I) Inhibitors/Modulators

Scroll up

Scroll down

Adenosine Receptor Ligands

Angiotensin II receptor (AT1)

Endothelin receptor antagonist (type A specific)

Scroll up

Scroll down

Heat Shock Proteins HSP90 Inhibitors

Scroll up

Scroll down

Hedgehog Signaling Pathway Inhibitors

Scroll up

Scroll down

HMG-CoA reductase inhibitor

Scroll up

Scroll down

Androgen receptor

Glucocorticoid Receptor

RXRs (retinoid X receptors)

Scroll up

Scroll down

Glycoside Hydrolase

Neprilysin (MME)

PDE4 ( phosphodiesterase type 4)

PLA2 Inhibitors

Scroll up

Scroll down

Mutant-IDH1 Inhibitor

Mutant-IDH2 Inhibitor

Scroll up

Scroll down

IMPDH Inhibitor

Scroll up

Scroll down

Liver X receptor (LXR) Agonist/Modulator

RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist

STING (STIMULATOR OF INTERFERON GENES) AGONIST

Toll-like Receptor Agonist

Scroll up

Scroll down

Anti-angiogenesis

Anti-inflammatory

Arginase Inhibitor

Autotaxin Inhibitors

PLA2 Inhibitors

Prostanoid ligand

RIP1 (RECEPTOR INTERACTING PROTEIN 1) KINASE

TGFβ Kinase Inhibitor

Scroll up

Scroll down

Adenosine 2A Receptor Antagonist

Arginase Inhibitor

CD73 (ecto-5'-nucleotidase) Inhibitor

CBP/β-catenin Modulators

CoreDAC Inhibitors

IDO1 (Indoleamine 2,3-dioxygenase 1) Inhibitor

Zinc Finger Protein Degrader

Immunoproteasome Inhibitor

Liver X receptor (LXR) Agonist/Modulator

mTOR inhibitors

PD-1/PD-L1 CHECKPOINT INHIBITORS

PI3Kγ (GAMMA) Specific Inhibitors

PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors

RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist

SHP2 Phosphatase Inhibitor

STING (Stimulator of Interferon Genes) Agonist

SUMOylation Inhibitor

TGFβ Kinase Inhibitor

Toll-like Receptor Modulators

Scroll up

Scroll down

Topoisomerase I

Topoisomerase II

Scroll up

Scroll down

Kinesin (CENP-E) Inhibitor

Scroll up

Scroll down

G12C Mutant Inhibitors

G12D Mutant Inhibitors

KRAS-PDEδ Interaction Inhibitor

Pan-KRAS Inhibitors

SOS1 Inhibitors

Tri-complex KRAS inhibitors

Tri-complex KRAS G12C (ON) Inhibitor

Tri-complex KRAS-G12CV (ON) Inhibitor

Scroll up

Scroll down

Arginase Inhibitor

Glutaminase Inhibitor

IDH (Isocitrate Dehydrogenase) Inhibitors

IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor

MAT2A Inhibitor

Monocarboxylate Transporter 1 (MCT 1) Inhibitor

Monocarboxylate Transporter 4 (MCT 4)

OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator

Scroll up

Scroll down

Monocarboxylate Transporter 1 (MCT 1) Inhibitor

Scroll up

Scroll down

Scroll up

Scroll down

Neuroactive/BBB Penetrant

Orexin Receptor Antagonists

SDAM (Serotonin-Dopamine Activity Modulator)

TRK (Tropomyosin Receptor Kinase)(Tyrosine Receptor Kinase) Inhibitor

Scroll up

Scroll down

CBP/β-catenin Modulators

Gamma (γ) Secretase (GS) Inhibitors

Notch Signaling Inhibitors

Scroll up

Scroll down

CRM1 (exportin 1) Inhibitor(s)

Scroll up

Scroll down

HCV Protease Inhibitor

HIV-1 integrase Inhibitor

Oxidoreductase Inhibitor

P-p68 (Phosphorylated-p68 RNA Helicase) Inhibitor

Thymidylate synthase inhibitor

WRN Helicase Inhibitor

Scroll up

Scroll down

p53–MDM2 Interaction Inhibitor

p53 Reactivator

Scroll up

Scroll down

PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors

SHP2 Phosphatase Inhibitor

Wip1 Phosphatase Inhibitor

Scroll up

Scroll down

PARP (Poly (ADP-ribose) polymerase)

Scroll up

Scroll down

Stem cell research

Scroll up

Scroll down

NADD8-Activating Enzyme Inhibtor

Proteasome Inhibitor

SUMOylation Inhibitor

Ubiquitin-Activating Enzyme Inhibitor

USP1 (Ubiquitin Specific Protease 1)

Scroll up

Scroll down

Quick Search:

Home > Kinase Inhibitors > Syk (Spleen Tyrosine Kinase) > GS-9973 (Entospletinib)

GS-9973 (Entospletinib)

Spleen tyrosine kinase (Syk), a non-receptor cytoplasmic, BCR-associated enzyme, is expressed in hematopoietic tissues and is often overexpressed in hematopoeitic malignancies. GS-9973 (Entospletinib) is a highly selective and orally efficacious inhibitor of spleen tyrosine kinase (Syk) with an IC50 of 7.7 nM. It inhibits the activity of Syk, which inhibits B-cell receptor (BCR) signaling and leads to an inhibition of tumor cell activation, migration, adhesion and proliferation. It is currently in clinical evaluation for autoimmune and oncology indications.

Catalog NO:	CT-GS9973
Synonym:	Entospletinib
CAS NO:	1229208-44-9
Mol. Formula:	C₂₃H₂₁N₇O
MW:	411.5

** A recrystallized crystalline powder/flakes (see attached picture), clean (>99% by HPLC), + impeccable 1H-NMR, coming with a perfect Quantitative Elemental Analysis. Bulk in stock. Ship within 1 day.

Pricing and OrderingTechnical Data

QC & Certificates

References

NO	Size	Price	In Stock	Quantity
1	10 mg	$80.00	YES
2	50 mg	$160.00	YES
3	100 mg	$260.00	YES

Bulk Inquiry: (Contact Us)

Toll-free: 1-877-343-6578 (US and Canada only)

Phone: 317-598-0828;

Email: sales@chemietek.com;

Add To Cart

Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99% Purity (HPLC, detected at 214 and 254 nm)

Original QC Data : HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis

Please Pick Batch NO:

GS-9973, Curent Lot, Certificate of Analysis
GS-9973, Current Lot, NMR
GS-9973, Current Lot, HPLC-MS
GS-9773, Lot 01, Appearance (color).pdf

1. K. S. Currie, et al., Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase, J. Med. Chem., April 6, 2014

Northeast Business Center, 7301 E. 90th Street, Suite 117,Indianapolis, IN 46256, USA;
Tel: 317-598-0828, Toll-free: 1-877-343-6578 (US and Canada only);Fax: 317-598-0835; info@chemietek.com
Copyright © 2014 Chemietek. All Rights Reserved.