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GLPG-0634 (Filgotinib)
GLPG0634 (Filgotinib)* is the first orally-available, selective inhibitor of JAK1. In vitro, it selectively inhibits JAK1 and JAK2 with IC50 values of 10 nM and 28 nM, respectively, selective over JAK3 and TYK2 (IC50 Values of 810 nM and 116 nM, respectively), and a panel of 150 other kinases. However, when tested in vivo it selectively inhibits JAK1, displaying a 30-fold potency over JAK2. It is currently in clinical evaluation for immune-inflammatory associated diseases.
Catalog NO: CT-GLPG
Synonym: Filgotinib
CAS NO: 1206161-97-8
Mol. Formula: C21H23N5O3S∙0.2H2O
MW: 429.1
** in vivo Grade Material. >99.5%Pure. A recrystallized white powder (Pic Attached), clean and impeccable, with quantitative elemental analysis. Bulk stock. Prompt.