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Home > Kinase Inhibitors > JAK1 Selective > GLPG-0634 (Filgotinib)

GLPG-0634 (Filgotinib)

GLPG0634 (Filgotinib)* is the first orally-available, selective inhibitor of JAK1. In vitro, it selectively inhibits JAK1 and JAK2 with IC50 values of 10 nM and 28 nM, respectively, selective over JAK3 and TYK2 (IC50 Values of 810 nM and 116 nM, respectively), and a panel of 150 other kinases. However, when tested in vivo it selectively inhibits JAK1, displaying a 30-fold potency over JAK2. It is currently in clinical evaluation for immune-inflammatory associated diseases.

Catalog NO:	CT-GLPG
Synonym:	Filgotinib
CAS NO:	1206161-97-8
Mol. Formula:	C₂₁H₂₃N₅O₃S∙0.2H₂O
MW:	429.1

** in vivo Grade Material. >99.5%Pure. A recrystallized white powder (Pic Attached), clean and impeccable, with quantitative elemental analysis. Bulk stock. Prompt.

Pricing and OrderingTechnical Data

QC & Certificates

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NO	Size	Price	In Stock	Quantity
1	10 mg	$100.00	YES
2	50 mg	$250.00	YES
3	100 mg	$400.00	YES
4	200 mg	$700.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99% (HPLC at 214 and 254 nm)

Original QC Data : HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis

Please Pick Batch NO:

GLPG-0634, Current Lot, NMR
GLPG-0634, Current Lot, HPLC-MS
GLPG0634, Lot 01, 0.2H2O, COA.pdf
GLPG0634 (Filgotinib), Lot 01, Visual Appearance.pdf

1. L. Van Rompaey, et al., Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases, J Immunol. 2013 Oct 1, 191(7):3568-77.

* The structure has been disclosed by authoritative sources. A wrong structure of this product, with CAS No: 1206101-20-3, Empirical Formula: C23H18N6O2, Mol. Wt: 410.43, is being offered in marketplace. Buyer beware!!

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