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Home > KRAS Pathway Inhibitors > G12C Mutant Inhibitors > GDC-6036

GDC-6036

Divarasib (GDC-6036) is an orally available, potent and selective inhibitor of KRAS G12C mutant with an IC₅₀ of <0.01 μM, and an EC₅₀ of 2 nM in K-Ras G12C-alkylation HCC1171 cells.

Catalog NO:	CT-G6036
Synonym:	Divarasib
CAS NO:	2417987-45-0
Mol. Formula:	C29H32ClF4N7O2
MW:	622.1

** in vivo Quality Material. >99% by achiral and chiral HPLCs (attached), with Confirmed Activity (IC ₅₀ = 8 nM*). Hemihydrtae, validated by a spot-on Elemental Analysis. Bulk (Discounted price for 0.5, 1, 2G, …,). Prompt.

Pricing and OrderingTechnical Data

QC & Certificates

References

NO	Size	Price	In Stock	Quantity
1	5 mg	$150.00	YES
2	10 mg	$220.00	YES
3	50 mg	$660.00	YES
4	100 mg	$1,000.00	YES

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Toll-free: 1-877-343-6578 (US and Canada only)

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : >99% by Achiral and Chiral HPLCs

Original QC Data : Achiral and Chiral HPLCs, MS, NMR, and Quantitative Elemental Analysis Report

Please Pick Batch NO:

GDC-6036, Lot 01, Certificate of Analysis.pdf
GDC-6036, Lot 01, Visual Appearance .pdf
C_K, GDC-6036, Lot 01, Achiral HPLC.pdf
C_K, GDC-6036, Lot 01, Chiral HPLC.pdf
C_K, GDC-6036, Lot 01, NMR.pdf

* Assay Method: K-Ras G12C.SOS1.Raf RBD Homogeneous Time-Resolved Fluorescence (HTRF) assay for inhibition of GTP exchange.

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