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EPZ-5676 (Pinometostat)
EPZ-5676 (Pinometostat) is a potent, selective and S-adenosyl methionine (SAM) competitive inhibitor of DOT1L methyltransferase (Ki = 80 pM), displaying 37,000-fold selectivity over all other methyltransferases tested. It inhibits H3K79 methylation and MLL-fusion target gene expression, and potently and selectively kills acute leukemia cell lines bearing MLL translocations. It is currently in clinical trials.
Catalog NO: CT-EPZ676
Synonym: Pinometostat, EPZ5676
CAS NO: 1380288-87-8
Mol. Formula: C30H42N8O3• 0.5HCl
MW: 580.9
** in vivo Quality Material. >99% purity by Achiral and Chiral HPLCs (Attached). A white Crystalline Powder. Bulk stock. Ship within 1 day