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Home > Kinase Inhibitors > PI3K - p110 Beta (β) Specific > AZD8186

AZD8186

AZD8186 is a metabolically stable and pharmacologically excellent PI3Kβ/δ isoform-selective inhibitor. It is orally available, potent and selective. Enantiomerically pure AZD8186 inhibits PI3Kβ and PI3Kδ in cellular assays with IC50 values of 3 nM and 17 nM, respectively, highly selective over PI3Kα (IC50 = 752 nM). It has demonstrated a profound pharmacodynamics modulation of p-Akt in PTEN-deﬁcient PC3 prostate tumor bearing mice after oral administration, and showed a complete inhibition of tumor growth in the mouse PTEN-deﬁcient PC3 prostate tumor xenograft model (ref. 1).

Catalog NO:	CT-A8186
Synonym:	AZD-8186
CAS NO:	1627494-13-6
Mol. Formula:	C24H25F2N3O4 ∙0.2H2O
MW:	461.1

** in vivo Quality Material. A snow-white crystalline solid (picture attached), >99.5% by Achiral and Chiral HPLCs, coming with a quantitative microanalysis. Bulk stock! Same day shipping.

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NO	Size	Price	In Stock	Quantity
1	10 mg	$120.00	YES
2	50 mg	$320.00	YES
3	100 mg	$540.00	YES

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Solubility : In DMSO

Storage : Refer to Certificate of Analysis

Purity : >99.8 Chemical and Enantiomerical Purity (By HPLC and Chiral HPLC)

Original QC Data : HPLC, Chiral HPLC, NMR and Quantitative Elemental Analysis

Please Pick Batch NO:

AZD8186, Lot 01, Certificate of Analysis.pdf
AZD8186, Lot 01, Visual Appearance.pdf
CTK, AZD8186, Lot 01, Achiral HPLC.PDF
CTK, AZD8186, Lot 01, Chiral HPLC.pdf
CTK, AZD8186, Lot 01, NMR in DMSO.pdf

1. B. Barlaam, et al, Discovery of (R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chrom ene-6-carboxamide (AZD8186): A Potent and Selective Inhibitor of PI3Kβ and PI3Kδ for the treatment of PTEN-deficient cancers. J. Med. Chem. 2015, 58, p943−962

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