AZD6244 (Selumetinib) - Chemietek

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Home > Kinase Inhibitors > MEK/MAPK > AZD6244 (Selumetinib)

AZD6244 (Selumetinib)

AZD6244 (Selumetinib) is a potent, selective and orally available small molecule inhibitor of MEK1/2 with an enzymatic IC50 value of 14 nM against MEK1. Block ERK1/2 phosphorylation with an IC50 value of 10 nM. Display broad antitumor activities in cell lines and in animal models either as a single agent, or in combination with other antitumor agents.

Catalog NO:	CT-A6244
Synonym:	ARRY-142886, Selumetinib
CAS NO:	606143-52-6
Mol. Formula:	C₁₇H₁₅BrClFN₄O₃ ∙ 0.3H₂O
MW:	463.1

** in vivo Quality Material. A clean product with 99.5% chemical purity. Bulk stock. Prompt.

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NO	Size	Price	In Stock	Quantity
1	50 mg	$70.00	YES
2	200 mg	$140.00	YES
3	500 mg	$250.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0 °C (short term), -20 °C (long term), desiccated

Purity : 99.5% (HPLC)

Original QC Data : HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis

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AZD-6244 (Selumetinib), Lot CT-009,, Certificate of Analysis.pdf

1. Yeh, T. C., et al, Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor, Clin Cancer Res. 13(5):1576-83 (2007).

2. Friday, B.B., et al., BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins, Cancer Res. 68(15):6145-53 (2008).

3. S. V. Holt, et al., The MEK1/2 inhibitor, Selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models, British Journal of Cancer (2012) 106, 858–866

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