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ABT-199 (Venetoclax)
BCL-2 is overexpressed in several hematologic malignancies, acting as a key regulator of the intrinsic apoptotic pathway by neutralizing pro-apoptotic molecules and inhibiting apoptosis. ABT-199 is an orally bioavailable, second-generation BH3-mimetic that specifically and potently inhibits BCL-2 (Ki<0.10 nM), highly selective over BCL-XL (Ki=48 nM, a 500-fold selectivity).
Catalog NO: CT-A199
Synonym: Venectoclax, GDC-0199
CAS NO: 1257044-40-8
Mol. Formula: C45H50ClN7O7S
MW: 868.4 (refer to Certificate of Analysis, batch-specific)
** in vivo Quality Material. >99.5% pure by HPLC (Attached). A multi-cycle recrystallized yellow powder, with Quantitative Elemental Analysis. Bulk stock (Discounted price for 2G, 5G, ..,). Same day shipping.