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2′,3′-cGAMP (cyclic [G(2’,5’)pA(3’,5’)p]) is the endogenous agonist for the STING (STimulator of INterferon Genes), a receptor crucial to activate the innate immune system. It is a noncanonical cyclic dinucleotide (CDN) produced as a second messenger in mammalian cells by the cytosolic cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. The binding potency of noncanonical 2′,3′-cGAMP for human STING is much better than that of the canonical 3′,3′-cyclic dinucleotides (CDNs) produced in bacterial, with a Kd of 4.6 nM compared to >1 μM for bacterial 3′,3′-CDNs (refs 1-3).
Catalog NO: CT-CGMAP
Synonym: 2', 3'-cyclic GMP-AMP Sodium Salt
CAS NO: 1441190-66-4
Mol. Formula: C20H22N10O13P2 ·2Na
MW: 718.4
** in vivo Quality material. >99% pure, snow-white (pic attached), disodium salt. Bulk stock (discounted price on sizes: 20, 50, 100, 200mg, …,). Same day shipping. 1mg powder equals 1.39 µmol