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Home > KRAS Pathway Inhibitors > Tri-complex KRASG12C (ON) Inhibitor > RMC-6291

RMC-6291

RMC-6291 is an orally bioavailable, covalent inhibitor of the active, guanosine triphosphate (GTP)-bound form of the oncogenic KRAS substitution mutation G12C, KRAS^G12C(ON). RMC-6291 forms a tri-complex with the intracellular chaperone protein and immunophilin cyclophilin A (CypA) and KRAS^G12C(ON). This tri-complex blocks KRAS^G12C(ON)-mediated signaling. RMC-6291 elicits deep and durable suppression on RAS pathway activity in KRAS^G12C tumor models (refs 1, 2).

Catalog NO:	CT-RMC6291
Synonym:	2641998-63-0
CAS NO:	RMC6291
Mol. Formula:	C55H78FN9O8
MW:	1012.3

** in vivo Quality Material. >99% by Achiral and Chiral HPLCs (attached). X-Ray-Verified Atropisomer Structure. Hemihydrate, validated by a spot-on Elemental Analysis. Bulk stock (Discounted price for 0.2, 0.5, 1G, …). Same Day Shipping.

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NO	Size	Price	In Stock	Quantity
1	5 mg	$400.00	YES
2	10 mg	$550.00	YES
3	50 mg	$1,700.00	YES

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : >99% by Achiral and Chiral HPLCs

Original QC Data : Achiral and Chiral HPLCs, MS, NMR, and Quantitative Elemental Analysis Report

Please Pick Batch NO:

RMC-6291 (RMC6291), Lot 01, Certificate of Analysis .pdf
RMC-6291, Lot 01, Visual Appearance.pdf
C_K, RMC-6291, Lot 01, Achiral HPLC.pdf
C_K, RMC-6291, Lot 01, Chiral HPLC.pdf

1. Nichols R J, et al. RMC-6291, a next-generation Tri-complex KRASG12C (ON) inhibitor, outperforms KRASG12C (OFF) inhibitors in preclinical models of KRASG12C cancers. Cancer Research, 2022, 82(12_Supplement): 3595-3595.

2. CHRISTOPHER J. SCHULZE, et al, Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS, SCIENCE, 17 Aug 2023, Vol 381, Issue 6659. pp. 794-799, DOI: 10.1126/science.adg9652

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