Zurletrectinib | ICP-723 - Chemietek

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Home > Kinase Inhibitors > TRK (Tropomyosin Receptor Kinase) (Tyrosine Receptor Kinase) > Zurletrectinib | ICP-723

Zurletrectinib | ICP-723

Zurletrectinib (ICP-723) is an orally active, potent and selective next-generation pan-TRK inhibitor with strong in vivo brain penetration and intracranial activity (TRKA/B/C IC₅₀ < 1nM). Demonstrates strong efficacy in overcoming resistance to first-generation TRK inhibitors (e.g., G595R mutation).

Catalog NO:	CT-ZURLE
Synonym:	ICP-723
CAS NO:	2403703-30-8
Mol. Formula:	C19H19F2N7O2
MW:	415.4

** in vivo Quality Material, >99% by Achiral and Chiral HPLCs (attached). Anhydrous, validated by a spot-on Quantitative Elemental Analysis. Bulk stock (discounted price for 0.5G, 1G, ..,). Same day shipping.

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	5 mg	$200.00	YES
2	10 mg	$300.00	YES
3	50 mg	$950.00	YES
4	200 mg	$2,000.00	YES

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : >99% by Achiral and Chiral HPLCs

Original QC Data : Achiral and Chiral HPLCs, NMR, and Quantitative Elemental Analysis Report

Please Pick Batch NO:

Zurletrectinib (ICP-723) Lot 01 Certificate of Analysis.pdf
Zurletrectinib (ICP-723) Lot 01 Visual Appearance.pdf
C_K, Zurletrectinib (ICP-723) Lot 01 Achiral HPLC.pdf
C_K, Zurletrectinib (ICP-723) Lot 01 Chiral HPLC.pdf

1. Roa, P., Foglizzo, V., Harada, G. et al. Zurletrectinib is a next-generation TRK inhibitor with strong intracranial activity against NTRK fusion-positive tumours with on-target resistance to first-generation agents. Br J Cancer 131, 601–610 (2024). https://doi.org/10.1038/s41416-024-02760-1

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