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XL-147 (Pilaralisib) is a potent, selective and orally bioavailable ATP-competitive small molecule inhibitor targeting pan-class I phosphatidylinositol 3 kinase (PI3K) family with IC50 values of 39, 383, 36 and 23 nM for p110 α, β, δ and γ isoforms, and is highly selective over mTOR (IC50 > 15000 nM), VPS34 (IC50 = 6975 nM), DNAPK (IC50 = 4750 nM). It is currently in clinical trials for cancer treatment.
Catalog NO: CT-XL147
Synonym: Pilaralisib, SAR245408
CAS NO: 934526-89-3
Mol. Formula: C25H25ClN6O4S•0.5HCl
MW: 559.3
** Grams in stock from Indianapolis USA. Ship within 1 day. CHEMIETEK offers XL-147 (CAS No. 934526-89-3) with the authoritatively confirmed structure (Ref. 3).