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VX-765 is a novel Caspase-1 inhibitor being investigated for the treatment of epilepsy, currently being developed by Vertex.  VX-765 is an orally-absorbed pro-drug of VRT-043198, a potent and selective inhibitor of ICE/caspase-1 sub-family caspases.  VRT-043198 exhibits 100-10,000-fold selectivity against other caspase-3 and -6-9.  In cultures of peripheral blood mononuclear cells and whole blood from healthy subjects stimulated with bacterial products, VRT-043198 inhibited the release of Interleukin (IL)-1beta and IL-18, but had little effect on the release of several other cytokines, including IL-1alpha, tumor necrosis factor-alpha, IL-6 and IL-8.
Catalog NO: CT-VX765
CAS NO: 273404-37-8
Mol. Formula: C24H33ClN4O6
MW: 508.99
** Grams in stock. A stereomerically pure (99% by HPLC and Chiral HPLC) product coming with an excellent Quantitative Elemental Analysis. Ship within 1 day.