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Home > Hydrolase Inhibitors/Modulators > Caspase-1 Inhibitor > VX-765

VX-765

VX-765 is a novel Caspase-1 inhibitor being investigated for the treatment of epilepsy, currently being developed by Vertex. VX-765 is an orally-absorbed pro-drug of VRT-043198, a potent and selective inhibitor of ICE/caspase-1 sub-family caspases. VRT-043198 exhibits 100-10,000-fold selectivity against other caspase-3 and -6-9. In cultures of peripheral blood mononuclear cells and whole blood from healthy subjects stimulated with bacterial products, VRT-043198 inhibited the release of Interleukin (IL)-1beta and IL-18, but had little effect on the release of several other cytokines, including IL-1alpha, tumor necrosis factor-alpha, IL-6 and IL-8.

Catalog NO:	CT-VX765
Synonym:
CAS NO:	273404-37-8
Mol. Formula:	C₂₄H₃₃ClN₄O₆
MW:	508.99

** Grams in stock. A stereomerically pure (99% by HPLC and Chiral HPLC) product coming with an excellent Quantitative Elemental Analysis. Ship within 1 day.

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	5 mg	$110.00	YES
2	10 mg	$150.00	YES
3	50 mg	$420.00	YES
4	100 mg	$720.00	YES
5	200 mg	$1,200.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : 99% chem. and stereomeric purity (HPLC and Chiral HPLC)

Original QC Data : HPLC-MS, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis

Please Pick Batch NO:

VX-765, lot 03,COA.pdf

1. Boxer, Matthew B.; Quinn, Amy M.; Shen, Min; Jadhav, Ajit; Leister, William; Simeonov, Anton; Auld, Douglas S.; Thomas, Craig J. A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety. ChemMedChem (2010), 5(5), 730-738.

2. Eda, Hiroyuki. Therapeutic potential for caspase inhibitors: Present and future. Design of Caspase Inhibitors as Potential Clinical Agents (2009), 251-287.

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