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Home > Hydrolase Inhibitors/Modulators > Caspase-1 > VX-765 (Belnacasan)

VX-765 (Belnacasan)

Belnacasan (VX-765) is a novel Caspase-1 inhibitor. VX-765 is an orally-absorbed pro-drug of VRT-043198, a potent and selective inhibitor of ICE/caspase-1 sub-family caspases. VRT-043198 exhibits 100-10,000-fold selectivity against other caspase-3 and -6-9. In cultures of peripheral blood mononuclear cells and whole blood from healthy subjects stimulated with bacterial products, VRT-043198 inhibited the release of Interleukin (IL)-1beta and IL-18, but had little effect on the release of several other cytokines, including IL-1alpha, tumor necrosis factor-alpha, IL-6 and IL-8.

Catalog NO:	CT-VX765
Synonym:	Belnacasan
CAS NO:	273404-37-8
Mol. Formula:	C₂₄H₃₃ClN₄O₆
MW:	508.99

** in vivo Quality Material. 99% by Achiral and Chiral HPLCs (attached). Anhydrous, va;idated by a spot-on Quantitative Elemental Analysis. Bulk stock. Ship within 1 day

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NO	Size	Price	In Stock	Quantity
1	10 mg	$100.00	YES
2	50 mg	$300.00	YES
3	100 mg	$480.00	YES

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : 99% Pure by Achiral and Chiral HPLCs

Original QC Data : Achiral and Chiral HPLCs, MS, NMR, and Quantitative Elemental analysis Report

Please Pick Batch NO:

VX-765 Lot 03 Certificate of Analysis.pdf

1. Boxer, Matthew B.; Quinn, Amy M.; Shen, Min; Jadhav, Ajit; Leister, William; Simeonov, Anton; Auld, Douglas S.; Thomas, Craig J. A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety. ChemMedChem (2010), 5(5), 730-738.

2. Eda, Hiroyuki. Therapeutic potential for caspase inhibitors: Present and future. Design of Caspase Inhibitors as Potential Clinical Agents (2009), 251-287.

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