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Home > Kinase Inhibitors > FAK (Focal Adhesion Kinase) > VS-4718 (PND-1186)

VS-4718 (PND-1186)

The cytoplasmic tyrosine kinase FAK (Focal Adhesion Kinase) is a signal transducer for integrins and is constitutively activated in various tumor cell types. It is involved in tumor cell invasion, migration and proliferation and plays a key role in the development, function and survival of cancer stem cells (CSCs). VS-4718 (PND-1186) is a potent, selective and orally bioavailable FAK inhibitor with IC50 at low nM range. It blocks fibronectin-stimulated FAK autophosphorylation of Tyr397, and prevents the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, resulting in the reduction of the number of cancer stem cells and inhibition of tumor cell migration, proliferation and survival. It displays strong anticancer activities both in vitro and in vivo, and is currently in clinical evaluation.

Catalog NO:	CT-VS4718
Synonym:	PND-1186
CAS NO:	1061353-68-1
Mol. Formula:	C₂₅H₂₆F₃N₅O₃
MW:	501.5

** 99.9% purity. in vivo Grade Material. Recrystallized white crystalline powder (pic attached). Anhydrous, validated with a spot-on quantitative elemental analysis. Bulk Stock! Prompt.

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	10 mg	$100.00	YES
2	50 mg	$250.00	YES
3	100 mg	$380.00	YES
4	200 mg	$650.00	YES
5	500 mg	$1,100.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : 99.9% (HPLC at 214 and 254 nm)

Original QC Data : HPLC-MS, ¹HNMR, Quantitative Elemental Analysis Report

Please Pick Batch NO:

VS-4718, Lot 3, Certificate of Analysis.pdf
VS-4718, lot 03, Visual Appearance.pdf

1.I. Tancioni, et al., FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth, Mol Cancer Ther. 2014 Aug;13(8):2050-61

2. W. F. Tam, et al, VS-4718, a Potent Focal Adhesion Kinase (FAK) Inhibitor, Exhibits Anticancer Activity in Leukemia Models in Vitro and in Vivo

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