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Voruciclib

Voruciclib (P1446A-05) is an oral, clinical-stage, potent and selective CDK inhibitor, blocking CDK9, the transcriptional regulator of MCL-1, with sub nanomolar potency, and suppressing MCL-1 expression in cell-based and xenograft models of DLBCL (ref 2).

Catalog NO:	CT-VORU
Synonym:	P1446A-05
CAS NO:	1000023-04-0
Mol. Formula:	C₂₂H₁₉ClF₃NO₅∙ H₂O
MW:	487.9

** in vivo Quality material. >99% by Achiral and Chiral HPLCs. A stereomerically pure single isomer* authenticated by 2-D NMR. Monohydrate, validated by a spot-on quantitative elemental analysis. Bulk stock!! Prompt.

Pricing and OrderingTechnical Data

QC & Certificates

References

NO	Size	Price	In Stock
1	5 mg	$150.00	YES
2	10 mg	$210.00	YES
3	50 mg	$600.00	YES
4	100 mg	$1,020.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : 100% stereomerical purity (Chiral HPLC), 99.5% chem purity (HPLC at 254).

Original QC Data : HPLC-MS, ¹HNMR, COSY, HSQC, NOESY, Chiral HPLC, and Quantitative Elemental Analysis

Please Pick Batch NO:

Voruciclib, Lot 01, Certificate of Analysis, Monohydrate.pdf
Voruciclib, Lot 01, Appearance (color).pdf

1. Adi Diab, et al, Phase I trial of the CDK 4/6 inhibitor, P1446A-05 (voruciclib) in combination with the BRAF inhibitor (BRAFi), vemurafenib in advanced, BRAF-mutant melanoma, Journal of Clinical Oncology, 2015 ASCO Annual Meeting (May 29 - June 2, 2015), Vol 33, No 15_suppl (May 20 Supplement), 2015: 9076

2. J. Dey, et al, Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition, Nature, Scientific Reports 7, Article number: 18007 (2017), doi:10.1038/s41598-017-18368-w

*A single isomer (out of four). Sophisticated instrumentation, such as NOESY and COSY, has been involved in reaffirmation of the structure.

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