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Voruciclib
Voruciclib (P1446A-05) is an oral, clinical-stage, potent and selective CDKs (CDKs 9, 6, 4) inhibitor with activity in multiple BRAF-mutant and wild type cell lines. It is currently in clinical trials in combination with BRAF inhibitor (PLX4032) to treat advanced BRAF-mutant melanoma (ref 1). It also potently blocks CDK9 (with sub nanomolar potency), the transcriptional regulator of MCL-1, suppressing MCL-1 expression in cell-based and xenograft models of DLBCL (ref 2).
Catalog NO: CT-VORU
Synonym: P1446A-05
CAS NO: 1000023-04-0
Mol. Formula: C22H19ClF3NO5∙ H2O
MW: 487.9
** in vivo grade material. 99.9-100% by achiral and chiral HPLCs. A stereomerically pure single isomer* (Clinically active isomer) with 100%ee, de. Monohydrate, validated by a spot-on quantitative elemental analysis. Bulk stock!! Ship within 1 day.