Volitinib (AZD6094, Savolitinib) - Chemietek

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Home > Kinase Inhibitors > c-Met > Volitinib (AZD6094, Savolitinib)

Volitinib (AZD6094, Savolitinib)

Volitinib (AZD6094, HMPL-504, Savolitinib) is an orally bioavailable ATP-competitive small molecule c-Met kinase inhibitor, binding to the enzyme potently with IC50 of 4 nM, and highly selective (>650 fold selectivity) over a panel of 265 kinases. Demonstrated selectivity for MET-driven disease, with MET amplified cell lines being most sensitive (IC50s of 1nM), and Displayed potent anti-tumor activity in cMET-dysregulated GC patient-derived tumor xenograft (PDX) models.

Catalog NO:	CT-A6094
Synonym:	AZD6094, HMPL-504, Savolitinib
CAS NO:	1313725-88-0
Mol. Formula:	C₁₇H₁₅N₉ ∙ 2HCl ∙2H₂O
MW:	454.3

** in vivo Grade Material. >99% pure by achiral and chiral HPLCs (attached). Bulk stock, Same day shipping.

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	5 mg	$100.00	YES
2	10 mg	$150.00	YES
3	50 mg	$400.00	YES

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Solubility : Soluble in DMSO (22.7mg/ml, 50mM)

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : 100% optical purity (Chiral HPLC), 99.8% chemical purity (HPLC at 215 and 254 nm),

Original QC Data : HPLC-MS, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis

Please Pick Batch NO:

Current, Certificate of Analysis
Volitinib, Current (Lot 01), Appearance (color).pdf
C_K, Volitinib, Lot 01, Achiral HPLC.pdf
C_K, Volitinib, Lot 01, Chiral HPLC.pdf
C_K, Volitinib, Lot 01, NMR.pdf

1. A.G. Schuller, et al, The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models. Clin Cancer Res. 2015 Jun 15; 21(12):2811-9. doi: 10.1158/1078-0432.CCR-14-2685. Epub 2015 Mar 16.

P. G. Gavine, et al, Volitinib, a potent and highly selective c-Met inhibitor, effectively blocks c-Met signaling and growth in c-MET amplified gastric cancer patient-derived tumor xenograft models, Mol Oncol. 2015 Jan; 9(1):323-33. doi: 10.1016/j.molonc.2014.08.015. Epub 2014 Sep 10.

*Confirmed precisely by a high-precision quantitative elemental analysis.

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