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Reagents for Biological Assays
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SMAC Mimics and Inhibitors of IAP
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Akt/(PKB (Protein Kinase B)
ALK (Anaplastic Lymphoma Kinase)
AMPK (AMP-Activated Protein Kinase)
ASK1 (Apoptosis Signal-regulating Kinase 1)
ATM (Ataxia Telangiectasia Mutated Kinase)
ATR (Ataxia Telangiectasia and Rad3 Related)
Aurora Kinase
Aurora A Kinase Selective
Aurora B Kinase Selective
Aurora C Kinase Selective
AXL (AXL Receptor Tyrosine Kinase)
Bcr-Abl/c-kit/PDGFR/Src
BTK (Bruton's Tyrosine Kinase)
BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)
CDC7 (Cell Division Cycle 7-related Protein Kinase)
CDK (Cyclin-dependent Kinase)
CDK2 Selective
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CHK (Checkpoint Kinase)
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c-Met
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EGFR Mutants
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ErbB
Erk (Extracellular signal regulated kinase)
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FGFR4 Specific
FLT3 (Fms-like Tyrosine Kinase 3)
IGF-1R
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LRRK2
MEK/MAPK
Mps1 (Monopolar Spindle 1)
mTOR
NIK (NF-κB-inducing kinase) Inhibitors
P21-Activated Kinases
P70S6K (Ribosomal Protein S6 Kinase)
PDGFR
PDK1
PI3K - p110 Alpha (α) Specific
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PIM
PKC (Protein Kinase C)
PKMYT1
PLK (Polo-like kinase)
PLK1 (Polo-like Kinase 1) Selective
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PTEF-b/CDK9
RAF (Rapidly Accelerated Fibrosarcoma)
RET (Rearranged During Transfection) Kinase
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ROS1 (Proto-oncogene Tyrosine-protein Kinase ROS)
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TGFβ (Transforming Growth Factor Beta (TGFβ) Receptor) Kinase
TOPK (T–lymphokine-activated killer cell–originated protein kinase)
TRK (Tropomyosin Receptor Kinase) (Tyrosine Receptor Kinase)
TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
VEGFR
WEE1
Factor VIIa inhibitor
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TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
Tubulin
Wee1
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
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EP300/CBP HAT (Histone Acetyltransferases) Inhibitor
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EZH2 (Mutant) METHYLTRANSFERASE INHIBITOR
HDAC (histone deacetylase) Inhibitors
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Lysine specific demethylase 1 (LSD1) Inhibitor
Menin-MLL interaction inhibitors
PRC2 (the catalytic subunit of polycomb repressive complex 2)
PRMT5 (Protein Arginine Methyltransferase 5) Inhibitors/Modulators
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Anti-angiogenesis
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Arginase Inhibitor
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Prostanoid ligand
RIP1 (RECEPTOR INTERACTING PROTEIN 1) KINASE
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CBP/β-catenin Modulators
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IDO1 (Indoleamine 2,3-dioxygenase 1) Inhibitor
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Immunoproteasome Inhibitor
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mTOR inhibitors
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Tri-complex KRASG12C (ON) Inhibitor
Tri-complex KRAS inhibitors
Arginase Inhibitor
Glutaminase Inhibitor
IDH (Isocitrate Dehydrogenase) Inhibitors
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
MAT2A Inhibitor
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Monocarboxylate Transporter 4 (MCT 4)
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
MTH1
Neuroactive/BBB Penetrant
Orexin Receptor Antagonists
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PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
SHP2 Phosphatase Inhibitor
Wip1 Phosphatase Inhibitor
PARP (Poly (ADP-ribose) polymerase)
Stem cell research
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Ubiquitin-Activating Enzyme Inhibitor
USP1 (Ubiquitin Specific Protease 1)
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AXL (AXL Receptor Tyrosine Kinase)
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BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)
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c-Met
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ErbB
Erk (Extracellular signal regulated kinase)
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PDGFR
PDK1
PI3K - p110 Alpha (α) Specific
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PI3K/mTOR
PIM
PKC (Protein Kinase C)
PKMYT1
PLK (Polo-like kinase)
PLK1 (Polo-like Kinase 1) Selective
PLK4 (Polo-like Kinase 4) Selective
PTEF-b/CDK9
RAF (Rapidly Accelerated Fibrosarcoma)
RET (Rearranged During Transfection) Kinase
RIP1 (Receptor Interacting Protein 1) Kinase
ROCK (Rho-Associated Protein Kinase)
ROS1 (Proto-oncogene Tyrosine-protein Kinase ROS)
Syk (Spleen Tyrosine Kinase)
TGFβ (Transforming Growth Factor Beta (TGFβ) Receptor) Kinase
TOPK (T–lymphokine-activated killer cell–originated protein kinase)
TRK (Tropomyosin Receptor Kinase) (Tyrosine Receptor Kinase)
TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
VEGFR
WEE1
Activated Factor VII (Factor VIIa)
Factor VIIa inhibitor
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p53-MDM2 Interaction Inhibitor
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PRC2 (the catalytic subunit of polycomb repressive complex 2) >
PKMYT1 Kinase Inhibitor
SMAC Mimics and Inhibitors of IAP
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TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
Tubulin
Wee1
Cell Metabolism Modulators
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
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CBP/P300 Bromodomain Inhibitor
CoreDAC Inhibitors
DNMT1 (DNA Methyltransferase 1) inhibitor
DOT1L Methyltransferase Inhibitor
EP300/CBP HAT (Histone Acetyltransferases) Inhibitor
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EZH2 (Mutant) METHYLTRANSFERASE INHIBITOR
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Lysine specific demethylase 1 (LSD1) Inhibitor
Menin-MLL interaction inhibitors
PRC2 (the catalytic subunit of polycomb repressive complex 2)
PRMT5 (Protein Arginine Methyltransferase 5) Inhibitors/Modulators
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PLA2 Inhibitors
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IDH (Isocitrate Dehydrogenase) Inhibitors
Mutant-IDH1 Inhibitor
Mutant-IDH2 Inhibitor
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
IMPDH Inhibitor
Immune Activation Agents/Modulators
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Arginase Inhibitor
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Prostanoid ligand
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TGFβ Kinase Inhibitor
Immunoproteasome Inhibitor
Immuno-oncology Modulators
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CD73 (ecto-5'-nucleotidase) Inhibitor
CBP/β-catenin Modulators
CoreDAC Inhibitors
IDO1 (Indoleamine 2,3-dioxygenase 1) Inhibitor
IKZF1/3 (Zinc Finger Protein 1/3)
Immunoproteasome Inhibitor
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mTOR inhibitors
PD-1/PD-L1 CHECKPOINT INHIBITORS
PI3Kγ (GAMMA) Specific Inhibitors
PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
SHP2 Phosphatase Inhibitor
STING (Stimulator of Interferon Genes) Agonist
SUMOylation Inhibitor
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Kinesin (CENP-E) Inhibitor
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G12D Mutant Inhibitors
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Tri-complex KRAS inhibitors
Liver X receptor (LXR) Agonist/Modulator
Metabolic Pathway Modulators
Arginase Inhibitor
Glutaminase Inhibitor
IDH (Isocitrate Dehydrogenase) Inhibitors
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
MAT2A Inhibitor
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Monocarboxylate Transporter 4 (MCT 4)
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
Monocarboxylate Transporter 1 (MCT 1) Inhibitor/Ligand
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Monocarboxylate Transporter 4 (MCT 4) Inhibitor
MTH1 (NUDT1, Human MutT Homologue)
MTH1
Neuroactive Research Products
Neuroactive/BBB Penetrant
Orexin Receptor Antagonists
SDAM (Serotonin-Dopamine Activity Modulator)
TRK (Tropomyosin Receptor Kinase)(Tyrosine Receptor Kinase) Inhibitor
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CBP/β-catenin Modulators
Gamma (γ) Secretase (GS) Inhibitors
Notch Signaling Inhibitors
Nuclear Export Protein Inhibitors/Modulators
CRM1 (exportin 1) Inhibitor(s)
Other Enzyme Inhibitors/Modulators
HCV Protease Inhibitor
HIV-1 integrase Inhibitor
Oxidoreductase Inhibitor
P-p68 (Phosphorylated-p68 RNA Helicase) Inhibitor
Thymidylate synthase inhibitor
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
PD-1/PD-L1 Checkpoint Inhibitors
p53–MDM2 Inhibitors/Modulators
p53–MDM2 Interaction Inhibitor
p53 Reactivator
PCNA (Proliferating Cell Nuclear Antigen)
PDE4 ( Phosphodiesterase Type 4) Inhibitor/Modulators
Phosphatase Inhibitors/Modulators
PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
SHP2 Phosphatase Inhibitor
Wip1 Phosphatase Inhibitor
PLA2 (Phospholipase A2) Inhibitor
Polymerase Inhibitor/Modulator
PARP (Poly (ADP-ribose) polymerase)
PPARG Agonist (Peroxisome Proliferator-activated Receptor Gamma Agomist)
Reagents for Biological Assays
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SMAC Mimics and Inhibitors of IAP
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Stem cell research
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Zinc Finger Protein (IKZF1/3) Degrader
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SHP2 Phosphatase Inhibitor
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TNO155
TNO155
TNO155 (Batoprotafib) is a highly potent (IC50 = 11 nM), selective and orally bioavailable allosteric small-molecule inhibitor of SHP2.
Catalog NO:
CT-TNO155
Synonym:
Batoprotafib, TNO-155
CAS NO:
1801765-04-7
Mol. Formula:
C18H24ClN7OS
MW:
422.0 (refer to the Certificate of Analysis, batch-specific)
** in vivo Quality material. >99.5% Pure by Achiral and Chiral HPLCs (Attached). Free base (salt-free), validated by a spot-on microanalysis, made for in vivo studies. Bulk stock (ask for quote on 0.5G, 1G, 2G, …). Same day shipping.
Pricing and Ordering
Technical Data
QC & Certificates
References
NO
Size
Price
In Stock
Quantity
1
5 mg
$100.00
YES
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2
10 mg
$150.00
YES
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9
10
3
50 mg
$420.00
YES
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2
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8
9
10
4
100 mg
$650.00
YES
--Select--
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2
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8
9
10
5
200 mg
$1,050.00
YES
--Select--
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9
10
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Solubility :
Refer to Certificate of Analysis
Storage :
Refer to Certificate of Analysis
Purity :
>99% by Achiral and Chiral HPLCs
Original QC Data :
Achiral and Chiral HPLCs, MS, NMR, and Quantitative Elemental Analysis Report
Please Pick Batch NO:
2
TNO155, Lot 02, Certificate of Analysis.pdf
TNO155, Lot 02, Visual Apearance .pdf
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