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Home > Epigenetics Resch Products > PRMT5 (Protein Arginine Methyltransferase 5) Inhibitors/Modulators > TNG-462 (Vopimetostat)

TNG-462 (Vopimetostat)

Vopimetostat (TNG-462) is an orally available and selective MTA-cooperative PRMT5 inhibitor. Vopimetostat (TNG-462) is more potent and selective with much improved DMPK properties than previously disclosed cooperative PRMT5 inhibitor TNG-908 (Ralometostat) (ref 1).

Catalog NO:	CT-TNG462
Synonym:	TNG462, Vopimetostat
CAS NO:	2760483-96-1
Mol. Formula:	C28H36N6O2S
MW:	520.7 (or refer to the Certificate of Analysis, batch-specific)

** in vivo Quality material. 99.5% Pure by achiral and chiral HPLCs (Attached). Monohydrate, validated by a spot-on Quantitative Elemental Analysis. Bulk stock (discounted price for 0.5G, 1G, 2G, …). Same day shipping.

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NO	Size	Price	In Stock	Quantity
1	5 mg	$150.00	YES
2	10 mg	$200.00	YES
3	50 mg	$650.00	YES
4	100 mg	$1,100.00	YES

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : >99% by Achiral and Chiral HPLCs

Original QC Data : Achiral and Chiral HPLCs, MS, NMR, and Quantitative Elemental Analysis Report

There is no COA file for this product

1. K. M. Cottrell, et al., Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion, J. Med. Chem. 2025, 68, 5, 5097–5119

2. K. J. Briggs, et al, TNG462 is a potential best-in-class MTA-cooperative PRMT5 inhibitor for the treatment of MTAP-deleted solid tumors. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl): Abstract nr 4970

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