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TNG-260
TNG-260 is a first-in-class, orally active, potent, and CoREST-selective deacetylase inhibitor. It inhibits HDAC1 with 10-fold selectivity over HDAC3 in cells, and 500-fold selectivity for the CoREST complex over the other HDAC1-containing complexes, NuRD and Sin3 (ref 1). TNG-260 reverses the immune evasion phenotype caused by loss of STK11 and induces tumor regressions in an STK11-mutant model in combination with α-PD1 (ref 1).
Catalog NO: CT-TNG260
Synonym: TNG260
CAS NO: 2935964-98-8
Mol. Formula: C20H18FN3O2S
MW: 383.4
** in vivo Quality Material. >99% by Achiral and Chiral HPLCs (attached). Validated Absolute Configuration. Anhydrous, verified by a spot-on Elemental Analysis. Textbook Quality. Bulk Stock (Discounted price for 0.5, 1, 2G, …). Prompt.