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Home > Kinase Inhibitors > ROS1 (Proto-oncogene Tyrosine-protein Kinase ROS) > Taletrectinib

Taletrectinib

Taletrectinib (DS-6051b) is an oral, potent, CNS-active, selective next-generation ROS1/NTRK inhibitor. Taletrectinib potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC₅₀s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib inhibits growth of ROS1 wild-type and ROS1-G2032R xenografts and other Crizotinib-resistant ROS1 mutants (refs. 1, 2, 3).

Catalog NO:	CT-TALET
Synonym:	AB106, DS-6051b
CAS NO:	1505515-69-4
Mol. Formula:	C23H24FN5O ∙ C6H10O4
MW:	551.6

** in vivo Quality Material, >99% pure by Achiral and Chiral HPLCs (Attached). Adipate salt, verified by a spot-on Elemental Analysis. Bulk stock (discounted price for 0.5G, 1G, 2G, …). Same day shipping.

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NO	Size	Price	In Stock	Quantity
1	10 mg	$150.00	YES
2	50 mg	$450.00	YES
3	100 mg	$700.00	YES

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : >99% by Achiral and Chiral HPLCs

Original QC Data : Achiral and Chiral HPLCs, NMR, and Quantitative Elemental Analysis Report

There is no COA file for this product

1. Katayama R, et al. The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models. Nat Commun. 2019;10(1):3604. Published 2019 Aug 9.

2. Fujiwara Y, et al. Safety and pharmacokinetics of DS-6051b in Japanese patients with non-small cell lung cancer harboring ROS1 fusions: a phase I study. Oncotarget. 2018;9(34):23729-23737. Published 2018 May 4.

3. Hitisha K. et al. Taletrectinib, a next generation selective ROS1 inhibitor, inhibits growth of ROS1 wild-type and ROS1-G2032R xenografts [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 5612.

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