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Home > Bcl-2 Protein Inhibitors/Degraders > Bcl-2 Family Protein Inhibitors > Sonrotoclax (BGB-11417)

Sonrotoclax (BGB-11417)

Sonrotoclax (BGB-11417) is a second-generation BCL-2 inhibitor with higher potency than the first-generation BCL-2 inhibitor Venetoclax (ABT-199. Our Product No: CT-A199). Exhibits strong in vitro and in vivo inhibitory activity against both WT Bcl-2 and the Venetoclax-resistant mutants, as well as excellent selectivity over BCL-XL without obvious cytochrome P450 inhibition (refs 1, 2). Sonrotoclax is being studied in combination with Zanubrutinib (Our Prod. NO. CT-ZANU) for chronic lymphocytic leukemia (CLL) and other cancers.

Catalog NO:	CT-BGB11417
Synonym:	BGB-11417
CAS NO:	2383086-06-2
Mol. Formula:	C49H59N7O7S
MW:	890.1 (or refer to the Certificate of Analysis, batch-specific)

** in vivo Quality Material. >99% Pure by Achiral and Chiral HPLCs (attached). Hemihydrate, verified by a spot-on Elemental Anlysis. Bulk stock (Discounted price for 0.2, 0.5, 1G, …). Same Day Shipping.

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NO	Size	Price	In Stock	Quantity
1	5 mg	$150.00	YES
2	10 mg	$200.00	YES
3	50 mg	$650.00	YES
4	100 mg	$1,000.00	YES

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : 99% by Achiral and Chiral HPLCs

Original QC Data : Achiral and Chiral HPLCs, MS, NMR, and Quantitative Elemental Analysis Report

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Sonrotoclax (BGB-11417) Lot 01 Certificate of Analysis.pdf

1. Y. H. Guo, et al, Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2 , J Med Chem, 2024 May 23;67(10):7836-7858. doi: 10.1021

2. J. Y. Liu, et al, Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy, Blood. 2024 May 2;143(18):1825-1836. doi: 10.1182/blood.2023019706

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