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SCH900353 (MK-8353)
MK-8353 (SCH-900353) is an orally bioavailable potent inhibitor targeting activated ERK1/2 with IC50 values of 23.0 and 8.8 nM, respectively, and nonactivated ERK2 with IC50 of 0.5 nM, highly selective over a panel of 227-human kinase; decreases levels of pERK1, pERK2, and ribosomal S6 kinase (pRSK) protein formation, with complete suppression of pERK1 and pERK2 observed at 30 nM in A2058 cells; inhibits the in vitro proliferation of a panel of BRAFV600-mutant and RAS-mutant cancer cell lines; displays in vivo antitumor efficacy against BRAFV600 mutant Colo-205 colon cancer model and the BRAFV600 mutant SK-MEL-28 melanoma model.
Catalog NO: CT-SCH353
Synonym: MK-8353
CAS NO: 1184173-73-6
Mol. Formula: C37H41 N9O3S • H2O
MW: 709.9
** in vivo Quality Material. 99.8-100% purity by achiral and chiral HPLCs (attached), monohydrate, validated by a spot-on quantitative microanalysis, made for in vivo studies. Bulk stock. Prompt.