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Home > Immuno/Inflammatory Mediators > Anti-inflammatory > Rofecoxib

Rofecoxib

Rofecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that has now been withdrawn over safety concerns. It was marketed by Merck & Co. to treat osteoarthritis, acute pain conditions, and dysmenorrhoea. Cyclooxygenase (COX) has two well-studied isoforms, called COX-1 and COX-2. COX-1 mediates the synthesis of prostaglandins responsible for protection of the stomach lining, while COX-2 mediates the synthesis of prostaglandins responsible for pain and inflammation. By creating “selective” NSAIDs that inhibit COX-2, but not COX-1, the same pain relief as traditional NSAIDs is offered, but with greatly reduced risk of fatal or debilitating peptic ulcers. Rofecoxib is a selective COX-2 inhibitor, or "coxib".

Catalog NO:	CT-RX001
Synonym:	Vioxx
CAS NO:	162011-90-7
Mol. Formula:	C₁₇H₁₄O₄S
MW:	314.36

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NO	Size	Price	In Stock	Quantity
1	250 mg	$80.00	YES
2	1 g	$200.00	YES

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Solubility : Soluble in DMSO and alcohols

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : > 99% (HPLC)

Original QC Data : ¹HNMR, HPLC

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Rofecoxib, Current Lot, COA

1. Bresalier, R.; Sandler, R.; Quan, H.; Bolognese, J.; Oxenius, B.; Horgan, K.; Lines, C.; Riddell, R. et al. (2005). "Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial".The New England journal of medicine 352 (11): 1092–1102.

2. Wolfe, MM (2004). "Rofecoxib, Merck, and the FDA". The New England journal of medicine 351 (27): 2875–8; author reply 2875–8.

3. Zhang, J.; Ding, E.; Song, Y. (2006). "Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials". Journal of the American Medical Association 296(13): 1619–1632.

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