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RMC-7977
RMC-7977 is a reversible, tri-complex RAS inhibitor with broad spectrum activity for both mutant and wild-type (WT) KRAS, NRAS, and HRAS variants (a RASMULTI(ON) inhibitor). Preclinically, RMC-7977 demonstrated potent activity against RAS-addicted tumors carrying various RAS genotypes, particularly cancer models with KRAS codon 12 mutations (KRAS G12X ). RMC-7977 led to tumor regressions and was well tolerated in diverse RAS-addicted preclinical cancer models. Additionally, RMC-7977 inhibited the growth of KRAS G12C cancer models that are resistant to KRAS G12C inhibitors due to restoration of RAS pathway signaling (ref. 1).
Catalog NO: CT-RMC7977
Synonym: RMC7977
CAS NO: 2765082-12-8
Mol. Formula: C47H60N8O6S∙H2O
MW: 883.1 (Or refer to the Certificate of Analysis, batch-specific)
** in vivo Quality Material. 99.9% Purity by Achiral and Chiral HPLCs (attached). Monohydrate, validated by a spot-on Elemental Analysis. Textbook Quality. Bulk stock (Discounted price for 0.2, 0.5, 1G, …). Same Day Shipping.
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