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RMC-6291 is an orally bioavailable, covalent inhibitor of the active, guanosine triphosphate (GTP)-bound form of the oncogenic KRAS substitution mutation G12C, KRASG12C(ON). RMC-6291 forms a tri-complex with the intracellular chaperone protein and immunophilin cyclophilin A (CypA) and KRASG12C(ON). This tri-complex blocks KRASG12C(ON)-mediated signaling. RMC-6291 elicits deep and durable suppression on RAS pathway activity in KRASG12C tumor models (refs 1, 2).
Catalog NO: CT-RMC6291
Synonym: 2641998-63-0
Mol. Formula: C55H78FN9O8
MW: 1012.3
** in vivo Quality Material. >99% Pure by Achiral and Chiral HPLCs (attached). Bulk stock (Discounted price for 0.2, 0.5, 1G, …). Same Day Shipping.