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Reagents for Biological Assays
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SMAC Mimics and Inhibitors of IAP
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Akt/(PKB (Protein Kinase B)
ALK (Anaplastic Lymphoma Kinase)
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ASK1 (Apoptosis Signal-regulating Kinase 1)
ATM (Ataxia Telangiectasia Mutated Kinase)
ATR (Ataxia Telangiectasia and Rad3 Related)
Aurora Kinase
Aurora A Kinase Selective
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Aurora C Kinase Selective
AXL (AXL Receptor Tyrosine Kinase)
Bcr-Abl/c-kit/PDGFR/Src
BTK (Bruton's Tyrosine Kinase)
BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)
CDC7 (Cell Division Cycle 7-related Protein Kinase)
CDK (Cyclin-dependent Kinase)
CDK2 Selective
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EphB4 (Ephrin Type-B Receptor 4) Kinase
ErbB
Erk (Extracellular signal regulated kinase)
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FGFR (Fibroblast Growth Factor Receptor)
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IGF-1R
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LRRK2
MEK/MAPK
Mps1 (Monopolar Spindle 1)
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NIK (NF-κB-inducing kinase) Inhibitors
P21-Activated Kinases
P70S6K (Ribosomal Protein S6 Kinase)
PDGFR
PDK1
PI3K - p110 Alpha (α) Specific
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PIM
PKC (Protein Kinase C)
PKMYT1
PLK (Polo-like kinase)
PLK1 (Polo-like Kinase 1) Selective
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PTEF-b/CDK9
RAF (Rapidly Accelerated Fibrosarcoma)
RET (Rearranged During Transfection) Kinase
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ROCK (Rho-Associated Protein Kinase)
ROS1 (Proto-oncogene Tyrosine-protein Kinase ROS)
Syk (Spleen Tyrosine Kinase)
TGFβ (Transforming Growth Factor Beta (TGFβ) Receptor) Kinase
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TRK (Tropomyosin Receptor Kinase) (Tyrosine Receptor Kinase)
TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
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WEE1
Factor VIIa inhibitor
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TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
Tubulin
Wee1
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
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DOT1L Methyltransferase Inhibitor
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EZH2 (Mutant) METHYLTRANSFERASE INHIBITOR
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Lysine specific demethylase 1 (LSD1) Inhibitor
Menin-MLL interaction inhibitors
PRC2 (the catalytic subunit of polycomb repressive complex 2)
PRMT5 (Protein Arginine Methyltransferase 5) Inhibitors/Modulators
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Arginase Inhibitor
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Prostanoid ligand
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CBP/β-catenin Modulators
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IDO1 (Indoleamine 2,3-dioxygenase 1) Inhibitor
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Immunoproteasome Inhibitor
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mTOR inhibitors
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PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
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G12C Mutant Inhibitors
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Tri-complex KRASG12C (ON) Inhibitor
Tri-complex KRAS inhibitors
Arginase Inhibitor
Glutaminase Inhibitor
IDH (Isocitrate Dehydrogenase) Inhibitors
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
MAT2A Inhibitor
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Monocarboxylate Transporter 4 (MCT 4)
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
MTH1
Neuroactive/BBB Penetrant
Orexin Receptor Antagonists
SDAM (Serotonin-Dopamine Activity Modulator)
TRK (Tropomyosin Receptor Kinase)(Tyrosine Receptor Kinase) Inhibitor
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HIV-1 integrase Inhibitor
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Thymidylate synthase inhibitor
p53–MDM2 Interaction Inhibitor
PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
SHP2 Phosphatase Inhibitor
Wip1 Phosphatase Inhibitor
PARP (Poly (ADP-ribose) polymerase)
Stem cell research
NADD8-Activating Enzyme Inhibtor
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Ubiquitin-Activating Enzyme Inhibitor
USP1 (Ubiquitin Specific Protease 1)
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ATM (Ataxia Telangiectasia Mutated Kinase)
ATR (Ataxia Telangiectasia and Rad3 Related)
Aurora Kinase
Aurora A Kinase Selective
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AXL (AXL Receptor Tyrosine Kinase)
Bcr-Abl/c-kit/PDGFR/Src
BTK (Bruton's Tyrosine Kinase)
BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)
CDC7 (Cell Division Cycle 7-related Protein Kinase)
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CDK2 Selective
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CLK (CDC2-like-Kinase)
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c-Met
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ErbB
Erk (Extracellular signal regulated kinase)
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FGFR4 Specific
FLT3 (Fms-like Tyrosine Kinase 3)
IGF-1R
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mTOR
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P70S6K (Ribosomal Protein S6 Kinase)
PDGFR
PDK1
PI3K - p110 Alpha (α) Specific
PI3K - p110 Beta (β) Specific
PI3K - p110 Delta (δ) Specific
PI3K - p110 Gamma (γ) Specific
PI3K - Pan
PI3K/mTOR
PIM
PKC (Protein Kinase C)
PKMYT1
PLK (Polo-like kinase)
PLK1 (Polo-like Kinase 1) Selective
PLK4 (Polo-like Kinase 4) Selective
PTEF-b/CDK9
RAF (Rapidly Accelerated Fibrosarcoma)
RET (Rearranged During Transfection) Kinase
RIP1 (Receptor Interacting Protein 1) Kinase
ROCK (Rho-Associated Protein Kinase)
ROS1 (Proto-oncogene Tyrosine-protein Kinase ROS)
Syk (Spleen Tyrosine Kinase)
TGFβ (Transforming Growth Factor Beta (TGFβ) Receptor) Kinase
TOPK (T–lymphokine-activated killer cell–originated protein kinase)
TRK (Tropomyosin Receptor Kinase) (Tyrosine Receptor Kinase)
TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
VEGFR
WEE1
Activated Factor VII (Factor VIIa)
Factor VIIa inhibitor
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BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)
CBP/β-catenin Modulators
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CDC7 (Cell Division Cycle 7-related Protein Kinase)
CHK (Checkpoint Kinase)
CLK (CDC2-like-Kinase)
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Endoplasmic Reticulum Stress Modulator (ERSM)
G-Quadruplex Ligand
IMPDH Inhibitor
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KRAS-PDEδ Interaction Inhibitor
KRAS-SOS1 Inhibitors
Menin-MLL interaction inhibitors
Mps1 (Monopolar Spindle 1)
Notch Signaling Inhibitors
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor
p53-MDM2 Interaction Inhibitor
PCNA (Proliferating Cell Nuclear Antigen)
PRC2 (the catalytic subunit of polycomb repressive complex 2) >
PKMYT1 Kinase Inhibitor
SMAC Mimics and Inhibitors of IAP
Survivin
TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
Tubulin
Wee1
Cell Metabolism Modulators
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Mutant Isocitrate Dehydrogenase-1 (IDH1) Inhibitor
Mutant Isocitrate Dehydrogenase-2 (IDH2) Inhibitor
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor
Chemotherapy
Chemotherapy Agents
CoREST-selective Deacetylase (CoreDAC) inhibitors
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DNA Repair Targeted Therapy
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Endoplasmic Reticulum Stress Modulator (ERSM)
Epigenetics Resch Products
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BET Family Protein Inhibitors
BET/Bromodomain (BDI and BDII) Selective Inhibitors
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BET/BRD9 Degrader
BET Bromodomain II (BDII) Selective Inhibitors
BET/Domain & Sub-set Selective Inhibitors
CBP/P300 Bromodomain Inhibitor
CoreDAC Inhibitors
DNMT1 (DNA Methyltransferase 1) inhibitor
DOT1L Methyltransferase Inhibitor
EP300/CBP HAT (Histone Acetyltransferases) Inhibitor
EZH1/2 Dual Inhibitors
EZH2 Methyltransferase Inhibitors
EZH2 (Mutant) METHYLTRANSFERASE INHIBITOR
HDAC (histone deacetylase) Inhibitors
HDAC1-Specific Inhibitors
HDAC3-Specific Inhibitors
HDAC6-Specific Inhibitors
Lysine specific demethylase 1 (LSD1) Inhibitor
Menin-MLL interaction inhibitors
PRC2 (the catalytic subunit of polycomb repressive complex 2)
PRMT5 (Protein Arginine Methyltransferase 5) Inhibitors/Modulators
PRMTs (Type I) Inhibitors/Modulators
Gamma (γ) Secretase (GS) Inhibitors
Glucocorticoid Receptor Antagonist/Modulator
Glutaminase Inhibitor
G-Protein-coupled Receptor Ligands
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Endothelin receptor antagonist (type A specific)
Heat Shock Protein Research Products
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Hippo Pathway Signaling Inhibitor
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HMG-CoA reductase inhibitor
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Androgen receptor
Glucocorticoid Receptor
RXRs (retinoid X receptors)
Hydrolase Inhibitors/Modulators
Autotaxin Inhibitor
Caspase-1 Inhibitor
Cathepsin K Inhibitor
Neprilysin (MME) Inhibitor
PDE4 ( phosphodiesterase type 4)
PLA2 Inhibitors
IDO1 (INDOLEAMINE 2,3-DIOXYGENASE 1) Inhibitors
IDH (Isocitrate Dehydrogenase) Inhibitors
Mutant-IDH1 Inhibitor
Mutant-IDH2 Inhibitor
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
IMPDH Inhibitor
Immune Activation Agents/Modulators
Liver X receptor (LXR) Agonist/Modulator
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
STING (STIMULATOR OF INTERFERON GENES) AGONIST
Toll-like Receptor Agonist
Immuno/Inflammatory Mediators
Anti-angiogenesis
Anti-fibrosis
Anti-inflammatory
Arginase Inhibitor
Autotaxin Inhibitors
PLA2 Inhibitors
Prostanoid ligand
RIP1 (RECEPTOR INTERACTING PROTEIN 1) KINASE
TGFβ Kinase Inhibitor
Immunoproteasome Inhibitor
Immuno-oncology Modulators
Adenosine 2A Receptor Antagonist
Arginase Inhibitor
CD73 (ecto-5'-nucleotidase) Inhibitor
CBP/β-catenin Modulators
CoreDAC Inhibitors
IDO1 (Indoleamine 2,3-dioxygenase 1) Inhibitor
IKZF1/3 (Zinc Finger Protein 1/3)
Immunoproteasome Inhibitor
Liver X receptor (LXR) Agonist/Modulator
mTOR inhibitors
PD-1/PD-L1 CHECKPOINT INHIBITORS
PI3Kγ (GAMMA) Specific Inhibitors
PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
SHP2 Phosphatase Inhibitor
STING (Stimulator of Interferon Genes) Agonist
SUMOylation Inhibitor
TGFβ Kinase Inhibitor
Toll-like Receptor Agonist
Immunosuppressants/Immunochemotherapy Agents
Isomerase Inhibitor/Modulator
Topoisomerase I
Topoisomerase II
Kinesin Ligand/Modulator
Kinesin (CENP-E) Inhibitor
KRAS Pathway Inhibitors
G12C Mutant Inhibitors
G12D Mutant Inhibitors
KRAS-PDEδ Interaction Inhibitor
Pan-KRAS Inhibitors
SOS1 Inhibitors
Tri-complex KRASG12C (ON) Inhibitor
Tri-complex KRAS inhibitors
Liver X receptor (LXR) Agonist/Modulator
Metabolic Pathway Modulators
Arginase Inhibitor
Glutaminase Inhibitor
IDH (Isocitrate Dehydrogenase) Inhibitors
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
MAT2A Inhibitor
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Monocarboxylate Transporter 4 (MCT 4)
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
Monocarboxylate Transporter 1 (MCT 1) Inhibitor/Ligand
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Monocarboxylate Transporter 4 (MCT 4) Inhibitor
MTH1 (NUDT1, Human MutT Homologue)
MTH1
Neuroactive Research Products
Neuroactive/BBB Penetrant
Orexin Receptor Antagonists
SDAM (Serotonin-Dopamine Activity Modulator)
TRK (Tropomyosin Receptor Kinase)(Tyrosine Receptor Kinase) Inhibitor
Notch/Wnt Signaling Pathway
CBP/β-catenin Modulators
Gamma (γ) Secretase (GS) Inhibitors
Notch Signaling Inhibitors
Nuclear Export Protein Inhibitors/Modulators
CRM1 (exportin 1) Inhibitor(s)
Other Enzyme Inhibitors/Modulators
HCV Protease Inhibitor
HIV-1 integrase Inhibitor
Oxidoreductase Inhibitor
P-p68 (Phosphorylated-p68 RNA Helicase) Inhibitor
Thymidylate synthase inhibitor
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
PD-1/PD-L1 Checkpoint Inhibitors
p53–MDM2 Interaction Inhibitor/Modulator
p53–MDM2 Interaction Inhibitor
PCNA (Proliferating Cell Nuclear Antigen)
PDE4 ( Phosphodiesterase Type 4) Inhibitor/Modulators
Phosphatase Inhibitors/Modulators
PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
SHP2 Phosphatase Inhibitor
Wip1 Phosphatase Inhibitor
PLA2 (Phospholipase A2) Inhibitor
Polymerase Inhibitor/Modulator
PARP (Poly (ADP-ribose) polymerase)
PPARG Agonist (Peroxisome Proliferator-activated Receptor Gamma Agomist)
Reagents for Biological Assays
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
SMAC Mimics and Inhibitors of IAP
Stem Cell Research Products
Stem cell research
STING (Stimulator of Interferon Genes) Agonist
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TEAD Inhibitor
Toll-like Receptor Agonist
Ubiquitin / Proteasome System
NADD8-Activating Enzyme Inhibtor
Proteasome Inhibitor
SUMOylation Inhibitor
Ubiquitin-Activating Enzyme Inhibitor
USP1 (Ubiquitin Specific Protease 1)
Wnt Signaling Pathway Modulators
YAP/TAZ Signaling Inhibitor
Zinc Finger Protein (IKZF1/3) Degrader
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SHP2 Phosphatase Inhibitor
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RMC-4630
RMC-4630
Vociprotafib (RMC-4630) is a potent, selective, and orally bioavailable allosteric inhibitor of SHP2.
Catalog NO:
CT-RMC4630
Synonym:
Vociprotafib, RMC4630
CAS NO:
2172652-48-9
Mol. Formula:
C20H27ClN6O2S∙1/5H2O
MW:
454.6 (or refer to Certificate of Analysis, batch-specific)
** in vivo Quality material. >99% Pure by achiral and chiral HPLCs (Attached). 1/5 hydrate, validated by a spot-on Quantitative Elemental Analysis. Bulk stock (ask for discounted quote on 0.5G, 1G, 2G, …). Same day shipping.
Pricing and Ordering
Technical Data
QC & Certificates
References
NO
Size
Price
In Stock
Quantity
1
5 mg
$180.00
YES
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10 mg
$250.00
YES
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50 mg
$800.00
YES
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100 mg
$1,400.00
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Solubility :
Refer to Certificate of Analysis
Storage :
Refer to Certificate of Analysis
Purity :
99% by achiral and chiral HPLCs
Original QC Data :
Achiral and Chiral HPLCs, MS, NMR, and Elemental Analysis Report
Please Pick Batch NO:
1
RMC-4630, Lot 01, Certificate of Analysis.pdf
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Quantity
Unit Price
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