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Home > Kinase Inhibitors > mTOR > Rapamycin (Sirolimus)

Rapamycin (Sirolimus)

Rapamycin is an immunosuppressant that is used primarily to prevent the rejection of organ and bone marrow transplant. It was first described as a potent inhibitor of interleukin-2 activation of lymphocytes (IC50 = 5 pM). It is now known that rapamycin specifically interacts with the cytosolic FK-binding protein 12 (FKBP12) to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1 (mTORC1). Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer, adipogenesis, diabetes, tuberous sclerosis, and cardiovascular disease.

Catalog NO:	CT-0622
Synonym:	Sirolimus
CAS NO:	53123-88-9
Mol. Formula:	C₅₁H₇₉NO₁₃
MW:	914.2

** A snow-white crystalline powder, >99.5% purity + a high-precision quantitative elemental analysis.

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NO	Size	Price	In Stock	Quantity
1	100 mg	$88.00	YES
2	200 mg	$150.00	YES

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Solubility : Soluble in DMSO and alcohols

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99.5% (HPLC) (trans- + cis- isomers), with cis- isomer ≤ 5%

Original QC Data : HPLC, 1H-NMR, and Quantitative Elemental Analysis

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Rapamycin, Lot 03, Certificate of Analysis.pdf
Rapamycin, lot 03, Visual Appearance.pdf

1. Kay, J.E., Kromwel, L., Doe, S.E.A., et al. Inhibition of T and B lymphocyte proliferation by rapamycin. Immunology 72 544-549 (1991).

2. Zhang, H.H., Huang, J., Düvel, K., et al. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS One 4(7) (2009).

3. Balgi, A.D., Fonseca, B.D., Donohue, E., et al. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4(9) (2009).

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