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Rapamycin (Sirolimus)
Rapamycin is an immunosuppressant that is used primarily to prevent the rejection of organ and bone marrow transplant. It was first described as a potent inhibitor of interleukin-2 activation of lymphocytes (IC50 = 5 pM).  It is now known that rapamycin specifically interacts with the cytosolic FK-binding protein 12 (FKBP12) to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1 (mTORC1). Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer, adipogenesis, diabetes, tuberous sclerosis, and cardiovascular disease.
Catalog NO: CT-0622
Synonym: Sirolimus
CAS NO: 53123-88-9
Mol. Formula: C51H79NO13
MW: 914.2
** A snow-white crystalline powder, >99.5% purity + a high-precision quantitative elemental analysis.