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Home > Immuno/Inflammatory Mediators > Prostanoid ligand > Ramatroban

Ramatroban

Ramatroban (BAY-u3405) is an approved human medication for the treatment of allergic rhinitis that has documented activity as an antagonist of the thromboxane receptor (TP receptor). BAY-u3405 is also an antagonist of the DP2 receptor with IC50 values of 100-170 nM. BAY-u3405 is more potent at the DP2 receptor than the TP receptor by 4-5 fold. BAY-u3405 is therefore a useful tool for the elucidation of PGD2/DP2 function in eosinophils, basophils, and other cells of the TH2 cell-type.

Catalog NO:	CT-RAM
Synonym:	Bay u3405
CAS NO:	116649-85-5
Mol. Formula:	C₂₁H₂₁FN₂O₄S
MW:	416.5

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NO	Size	Price	In Stock	Quantity
1	10 mg	$110.00	YES
2	50 mg	$400.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : > 99% chem and optical purity (HPLC and chiral HPLC)

Original QC Data : ¹HNMR, HPLC and Chiral HPLC

There is no COA file for this product

1. McKenniff, M.G., Norman, P., Cuthbert, N.J., et al. BAY u3405, a potent and selective thromboxane A2 receptor antagonist on airway smooth muscle in vitro.. Br J Pharmacol 104(3) 585-590 (1991).

2. Sugimoto, H., Shichijo, M., Iino, T., et al. An orally bioavailable small molecule antagonist of CRTH2, Ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. J Pharmacol Exp Ther 305 347-352 (2003).

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