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Kinase Inhibitors

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Activated Factor VII (Factor VIIa)

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Arginase Inhibitor

Adenosine Receptor Ligands

Autotaxin Inhibitor

Bcl-2 Protein Inhibitors/Degraders

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BCL-6 Protein Inhibitors

CD73 Immune Pathway Inhibitor/Modulator

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Cell Cycle Modulators

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Cell Metabolism Modulators

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CoREST-selective Deacetylase (CoreDAC) inhibitors

Degraders (Protein Degraders)

DNA Methyltransferase Inhibtors

DNA Repair Targeted Therapy

DNA/RNA Synthesis Inhibitor/Blocker

Endoplasmic Reticulum Stress Modulator (ERSM)

Epigenetics Resch Products

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Gamma (γ) Secretase (GS) Inhibitors

Glucocorticoid Receptor Antagonist/Modulator

Glutaminase Inhibitor

G-Protein-coupled Receptor Ligands

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Heat Shock Protein Research Products

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Hedgehog Signaling Pathway Modulators

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Hippo Pathway Signaling Inhibitor

HMG-CoA Reductase

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Hormone Receptor Modulators

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Hydrolase Inhibitors/Modulators

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IDO1 (INDOLEAMINE 2,3-DIOXYGENASE 1) Inhibitors

IDH (Isocitrate Dehydrogenase) Inhibitors

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IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor

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Immune Activation Agents/Modulators

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Immuno/Inflammatory Mediators

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Immunoproteasome Inhibitor

Immuno-oncology Modulators

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Immunosuppressants/Immunochemotherapy Agents

Isomerase Inhibitor/Modulator

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Kinesin Ligand/Modulator

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KRAS Pathway Inhibitors

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Liver X receptor (LXR) Agonist/Modulator

Metabolic Pathway Modulators

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Monocarboxylate Transporter 1 (MCT 1) Inhibitor/Ligand

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Monocarboxylate Transporter 4 (MCT 4) Inhibitor

MTH1 (NUDT1, Human MutT Homologue)

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Neuroactive Research Products

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Notch/Wnt Signaling Pathway

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Nuclear Export Protein Inhibitors/Modulators

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Other Enzyme Inhibitors/Modulators

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OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator

PD-1/PD-L1 Checkpoint Inhibitors

p53–MDM2 Interaction Inhibitor/Modulator

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PCNA (Proliferating Cell Nuclear Antigen)

PDE4 ( Phosphodiesterase Type 4) Inhibitor/Modulators

Phosphatase Inhibitors/Modulators

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PLA2 (Phospholipase A2) Inhibitor

Polymerase Inhibitor/Modulator

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PPARG Agonist (Peroxisome Proliferator-activated Receptor Gamma Agomist)

Reagents for Biological Assays

RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist

SMAC Mimics and Inhibitors of IAP

Stem Cell Research Products

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STING (Stimulator of Interferon Genes) Agonist

SUMO Pathway Modulator

Toll-like Receptor Agonist

Ubiquitin / Proteasome System

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Wnt Signaling Pathway Modulators

YAP/TAZ Signaling Inhibitor

Zinc Finger Protein (IKZF1/3) Degrader

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Akt/(PKB (Protein Kinase B)

ALK (Anaplastic Lymphoma Kinase)

AMPK (AMP-Activated Protein Kinase)

ASK1 (Apoptosis Signal-regulating Kinase 1)

ATM (Ataxia Telangiectasia Mutated Kinase)

ATR (Ataxia Telangiectasia and Rad3 Related)

Aurora A Kinase Selective

Aurora B Kinase Selective

Aurora C Kinase Selective

AXL (AXL Receptor Tyrosine Kinase)

Bcr-Abl/c-kit/PDGFR/Src

BTK (Bruton's Tyrosine Kinase)

BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)

CDC7 (Cell Division Cycle 7-related Protein Kinase)

CDK (Cyclin-dependent Kinase)

CHK (Checkpoint Kinase)

CLK (CDC2-like-Kinase)

CLK2 (CDC2-like Kinase 2)

DDK (Dbf4-dependent kinase)

DNA-PK (DNA-Dependent Protein Kinase)

EphB4 (Ephrin Type-B Receptor 4) Kinase

Erk (Extracellular signal regulated kinase)

FAK (Focal Adhesion Kinase)

FGFR (Fibroblast Growth Factor Receptor)

FLT3 (Fms-like Tyrosine Kinase 3)

JAK (Janus Kinase)

JAK1/JAK2 Selective

Mps1 (Monopolar Spindle 1)

NIK (NF-κB-inducing kinase) Inhibitors

P21-Activated Kinases

P70S6K (Ribosomal Protein S6 Kinase)

PI3K - p110 Alpha (α) Specific

PI3K - p110 Beta (β) Specific

PI3K - p110 Delta (δ) Specific

PI3K - p110 Gamma (γ) Specific

PKC (Protein Kinase C)

PLK (Polo-like kinase)

PLK1 (Polo-like Kinase 1) Selective

PLK4 (Polo-like Kinase 4) Selective

RAF (Rapidly Accelerated Fibrosarcoma)

RET (Rearranged During Transfection) Kinase

RIP1 (Receptor Interacting Protein 1) Kinase

ROCK (Rho-Associated Protein Kinase)

ROS1 (Proto-oncogene Tyrosine-protein Kinase ROS)

Syk (Spleen Tyrosine Kinase)

TGFβ (Transforming Growth Factor Beta (TGFβ) Receptor) Kinase

TOPK (T–lymphokine-activated killer cell–originated protein kinase)

TRK (Tropomyosin Receptor Kinase) (Tyrosine Receptor Kinase)

TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))

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Factor VIIa inhibitor

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Bcl-2 Family Protein Inhibitors

BCL-2 Selective Inhibitors

BCL-XL Protein Degrader

BCL-XL Selective Inhibitors

MCL-1 Selective Inhibitors

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CD73 (ecto-5'-nucleotidase) Inhibitor

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BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)

CBP/β-catenin Modulators

Cell Cycle/DNA Damage

CDK Inhibitors/Modulators

CDC7 (Cell Division Cycle 7-related Protein Kinase)

CHK (Checkpoint Kinase)

CLK (CDC2-like-Kinase)

DNA Replication Modulators/Breakers

Endoplasmic Reticulum Stress Modulator (ERSM)

G-Quadruplex Ligand

IMPDH Inhibitor

Kinesin (CENP-E) Inhibitor

KRAS-G12C Inhibitors

KRASG12C (ON) (Tri-complex) Inhibitor

KRAS-G12D Inhibitors

KRAS-PDEδ Interaction Inhibitor

KRAS-SOS1 Inhibitors

Menin-MLL interaction inhibitors

Mps1 (Monopolar Spindle 1)

Notch Signaling Inhibitors

OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor

p53-MDM2 Interaction Inhibitor

PCNA (Proliferating Cell Nuclear Antigen)

PRC2 (the catalytic subunit of polycomb repressive complex 2) >

PKMYT1 Kinase Inhibitor

SMAC Mimics and Inhibitors of IAP

TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))

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Monocarboxylate Transporter 1 (MCT 1) Inhibitor

Mutant Isocitrate Dehydrogenase-1 (IDH1) Inhibitor

Mutant Isocitrate Dehydrogenase-2 (IDH2) Inhibitor

OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor

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Chemotherapy Agents

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ATPases (BRG1/BRM)

BET Family Protein Degraders

BET Family Protein Inhibitors

BET/Bromodomain (BDI and BDII) Selective Inhibitors

BET/BRD4 Degrader

BET/BRD9 Degrader

BET Bromodomain II (BDII) Selective Inhibitors

BET/Domain & Sub-set Selective Inhibitors

CBP/P300 Bromodomain Inhibitor

CoreDAC Inhibitors

DNMT1 (DNA Methyltransferase 1) inhibitor

DOT1L Methyltransferase Inhibitor

EP300/CBP HAT (Histone Acetyltransferases) Inhibitor

EZH1/2 Dual Inhibitors

EZH2 Methyltransferase Inhibitors

EZH2 (Mutant) METHYLTRANSFERASE INHIBITOR

HDAC (histone deacetylase) Inhibitors

HDAC1-Specific Inhibitors

HDAC3-Specific Inhibitors

HDAC6-Specific Inhibitors

Lysine specific demethylase 1 (LSD1) Inhibitor

Menin-MLL interaction inhibitors

PRC2 (the catalytic subunit of polycomb repressive complex 2)

PRMT5 (Protein Arginine Methyltransferase 5) Inhibitors/Modulators

PRMTs (Type I) Inhibitors/Modulators

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Adenosine Receptor Ligands

Angiotensin II receptor (AT1)

Endothelin receptor antagonist (type A specific)

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Heat Shock Proteins HSP90 Inhibitors

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Hedgehog Signaling Pathway Inhibitors

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HMG-CoA reductase inhibitor

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Androgen receptor

Glucocorticoid Receptor

RXRs (retinoid X receptors)

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Autotaxin Inhibitor

Caspase-1 Inhibitor

Cathepsin K Inhibitor

Neprilysin (MME) Inhibitor

PDE4 ( phosphodiesterase type 4)

PLA2 Inhibitors

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Mutant-IDH1 Inhibitor

Mutant-IDH2 Inhibitor

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IMPDH Inhibitor

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Liver X receptor (LXR) Agonist/Modulator

RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist

STING (STIMULATOR OF INTERFERON GENES) AGONIST

Toll-like Receptor Agonist

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Anti-angiogenesis

Anti-inflammatory

Arginase Inhibitor

Autotaxin Inhibitors

PLA2 Inhibitors

Prostanoid ligand

RIP1 (RECEPTOR INTERACTING PROTEIN 1) KINASE

TGFβ Kinase Inhibitor

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Adenosine 2A Receptor Antagonist

Arginase Inhibitor

CD73 (ecto-5'-nucleotidase) Inhibitor

CBP/β-catenin Modulators

CoreDAC Inhibitors

IDO1 (Indoleamine 2,3-dioxygenase 1) Inhibitor

IKZF1/3 (Zinc Finger Protein 1/3)

Immunoproteasome Inhibitor

Liver X receptor (LXR) Agonist/Modulator

mTOR inhibitors

PD-1/PD-L1 CHECKPOINT INHIBITORS

PI3Kγ (GAMMA) Specific Inhibitors

PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors

RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist

SHP2 Phosphatase Inhibitor

STING (Stimulator of Interferon Genes) Agonist

SUMOylation Inhibitor

TGFβ Kinase Inhibitor

Toll-like Receptor Agonist

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Topoisomerase I

Topoisomerase II

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Kinesin (CENP-E) Inhibitor

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G12C Mutant Inhibitors

G12D Mutant Inhibitors

KRAS-PDEδ Interaction Inhibitor

Pan-KRAS Inhibitors

SOS1 Inhibitors

Tri-complex KRASG12C (ON) Inhibitor

Tri-complex KRAS inhibitors

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Arginase Inhibitor

Glutaminase Inhibitor

IDH (Isocitrate Dehydrogenase) Inhibitors

IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor

MAT2A Inhibitor

Monocarboxylate Transporter 1 (MCT 1) Inhibitor

Monocarboxylate Transporter 4 (MCT 4)

OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator

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Monocarboxylate Transporter 1 (MCT 1) Inhibitor

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Neuroactive/BBB Penetrant

Orexin Receptor Antagonists

SDAM (Serotonin-Dopamine Activity Modulator)

TRK (Tropomyosin Receptor Kinase)(Tyrosine Receptor Kinase) Inhibitor

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CBP/β-catenin Modulators

Gamma (γ) Secretase (GS) Inhibitors

Notch Signaling Inhibitors

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CRM1 (exportin 1) Inhibitor(s)

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HCV Protease Inhibitor

HIV-1 integrase Inhibitor

Oxidoreductase Inhibitor

P-p68 (Phosphorylated-p68 RNA Helicase) Inhibitor

Thymidylate synthase inhibitor

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p53–MDM2 Interaction Inhibitor

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PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors

SHP2 Phosphatase Inhibitor

Wip1 Phosphatase Inhibitor

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PARP (Poly (ADP-ribose) polymerase)

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Stem cell research

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NADD8-Activating Enzyme Inhibtor

Proteasome Inhibitor

SUMOylation Inhibitor

Ubiquitin-Activating Enzyme Inhibitor

USP1 (Ubiquitin Specific Protease 1)

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Home > Immuno/Inflammatory Mediators > Anti-inflammatory > PF-8380

PF-8380

PF-8380 is an orally bioavailable, potent and competitive inhibitor of autotaxin (IC = 2.8 nM in enzyme assay; 101 nM in human whole blood). It directly inhibits autotaxin activity, modulating lysophosphatidic acid (LPA) levels in vivo and in vitro, and reduces LPA levels both in plasma and at site of inflammation.

Catalog NO:	CT-PF8380
Synonym:
CAS NO:	1144035-53-9
Mol. Formula:	C22H21Cl2N3O5
MW:	478.3 (or refer to Certificate of Analysis, batch-specific)

** A white crystalline powder (picture attached. In contrast to YELLOW one on market by many other vendors). >99% pure (see attached QC docs). InVivoGrade. Same day shipping.

Pricing and OrderingTechnical Data

QC & Certificates

References

NO	Size	Price	In Stock	Quantity
1	10 mg	$110.00	YES
2	50 mg	$260.00	YES
3	100 mg	$420.00	YES
4	200 mg	$720.00	YES

Bulk Inquiry: (Contact Us)

Toll-free: 1-877-343-6578 (US and Canada only)

Phone: 317-598-0828;

Email: sales@chemietek.com;

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : >99% by HPLC (214 and 254 nm)

Original QC Data : HPLC, NMR and Quantitative Elemental Analysis Report

Please Pick Batch NO:

PF-8380. Lot 01, Certificate of Analysis.pdf
PF-8380, Lot 01, Visual Appearance (1.0).pdf

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