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PF-8380 is an orally bioavailable, potent and competitive inhibitor of autotaxin (IC = 2.8 nM in enzyme assay; 101 nM in human whole blood). It directly inhibits autotaxin activity, modulating lysophosphatidic acid (LPA) levels in vivo and in vitro, and reduces LPA levels both in plasma and at site of inflammation.
Catalog NO: CT-PF8380
CAS NO: 1144035-53-9
Mol. Formula: C22H21Cl2N3O5
MW: 478.3 (or refer to Certificate of Analysis, batch-specific)
** A white crystalline powder (picture attached. In contrast to YELLOW one on market by many other vendors). >99% pure (see attached QC docs). InVivoGrade. Same day shipping.