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PF-8380
PF-8380 is an orally bioavailable, potent and competitive inhibitor of autotaxin (IC = 2.8 nM in enzyme assay; 101 nM in human whole blood). It directly inhibits autotaxin activity, modulating lysophosphatidic acid (LPA) levels in vivo and in vitro, and reduces LPA levels both in plasma and at site of inflammation.
Catalog NO: CT-PF8380
Synonym:
CAS NO: 1144035-53-9
Mol. Formula: C22H21Cl2N3O5
MW: 478.3 (or refer to Certificate of Analysis, batch-specific)
** in vivo Quality material. >99% Purity. Monohydrate, validated by a spot-on Quantitative Elemental Analysis. Bulk stock. Same day shipping.