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PF-06840003 (EOS-200271)
PF-06840003 (EOS-200271) is a highly selective, orally bioavailable and neuroactive IDO-1 inhibitor. PF-06840003 reversed IDO-1-induced T-cell anergy in vitro. In vivo, PF-06840003 reduced intratumoral kynurenine levels in mice by >80% and inhibited tumor growth in multiple preclinical syngeneic models in mice, in combination with immune checkpoint inhibitors. PF-0684003 has favorable predicted human pharmacokinetic properties, including a predicted t1/2 of 16-19 hours (refs. 1, 2). It is currently in clinical evaluation.
Catalog NO: CT-PF0684
Synonym: EOS-200271, PF06840003
CAS NO: 198474-05-4
Mol. Formula: C12H9FN2O2
MW: 232.2 (or refer to Certificate of Analysis, batch-specific)
** 99.9% Pure, in vivo Quality material. A recrystallized powder (pic attached), Anhydrous, validated by a spot-on Quantitative Elemental Analysis. Bulk stock! Same day shipping.