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PF-06821497 (PF06821497)
PF-06821497 (optically pure R-enantiomer) (compound 23a, Ref. 1) is a small molecule inhibitor of Histone Methyltransferase (HMT) EZH2, potently and selectively inhibiting the activities of both wild-type (Ki = 0.3nM) and mutant (Y641N) (Ki < 0.1nM). It is currently in clinical evaluation to treat lymphoma.
Catalog NO: CT-PF0682
Synonym: PF06821497
CAS NO: 1844849-10-0
Mol. Formula: C22H24Cl2N2O5
MW: 467.3 (or refer to Certificate of Analysis, batch-specific)
** in vivo Grade Material. A white crystalline powder (see attached picture), 100% optically pure, with spot-on quantitative microanalysis . Bulk stock!! Same day shipping.