PF-06463922 (Lorlatinib) - Chemietek

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Home > Kinase Inhibitors > ALK (Anaplastic Lymphoma Kinase) > PF-06463922 (Lorlatinib)

PF-06463922 (Lorlatinib)

PF-06463922 (Lorlatinib) is an orally bioavailable and blood-brain-barrier (BBB) penetrable dual ALK/ROS1 inhibitor, a cyclic small molecule engineered from Crizotinib (CHEMIETEK Prod. NO: CT-PF0234). It is highly potent with Ki values of <0.02 nM, <0.07 nM, and 0.7 nM against ROS1, ALK (WT), and ALK (L1196M), respectively, and displays a broad-spectrum potency against ALK-Resistant Mutations (with IC50s at lower nM) (Ref 1).

Catalog NO:	CT-PF0646
Synonym:	Lorlatinib
CAS NO:	1454846-35-5
Mol. Formula:	C21H19FN6O2 ∙ 0.7xH2O
MW:	419.0

** in vivo Quality material. >99% by achiral and chiral HPLCs (attached), with a spot-on quantitative Elemental Analysis. Bulk stock (Discounted price for 1G, 2G, 5G, …, ). Same day Shipping.

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	50 mg	$120.00	YES
2	200 mg	$350.00	YES
3	500 mg	$650.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0 oC (short term), -20 oC (long term), Desiccated

Purity : >99.5% Chemical Purity (HPLC at 215 and 254 nm), 100% Optical Purity (by Chiral HPLC)

Original QC Data : HPLC-MS, Chiral HPLC and Quantitative Elemental Analysis

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PF-06463922, lot 03,Certificate of Analysis.pdf

TW Johnson, et al, J Med Chem. 2014 Jun 12; 57(11):4720-44, doi: 10.1021/jm500261q. Epub 2014 Jun 3. PubMed PMID: 24819116.

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