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Home > Kinase Inhibitors > ALK (Anaplastic Lymphoma Kinase) > PF-02341066

PF-02341066

PF-02341066 (R-Crizotinib) is a cell-permeable, specific ATP-competitive small-molecule inhibitor of c-Met (Ki =4 nM) and anaplastic lymphoma kinase (ALK) (IC50 = 28 nM).

Catalog NO:	CT-PF0234
Synonym:	Crizotinib
CAS NO:	877399-52-5
Mol. Formula:	C₂₁H₂₂Cl₂FN₅O ∙0.5H₂O
MW:	459.3

** in vivo Quality Material. >99.5% chemically and optically pure by achiral and chiral HPLCs. Hemihydrate, validated by a spot-on microanalysis. Bulk stock! Prompt.

Pricing and OrderingTechnical Data

QC & Certificates

References

NO	Size	Price	In Stock	Quantity
1	10 mg	$80.00	YES
2	50 mg	$180.00	YES
3	100 mg	$280.00	YES
4	200 mg	$450.00	YES
5	500 mg	$850.00	YES

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Solubility : Soluble in DMSO and water with 2 eq. of acid

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : 100% optical purity (Chiral HPLC), >99% purity (HPLC at 214 and 254 nm),

Original QC Data : HPLC-MS, ¹HNMR, Chiral HPLC, and Quantitative Elemental Analysis

Please Pick Batch NO:

PF-02341066, R-Crizotinib, Lot 08, Certificate of Analysis.pdf
C_K, PF-02341066, Lot 08, HPLC-MS.pdf
C_K, PF-02341066, Lot 08, Chiral HPLC.pdf
C_K, PF-02341066, Lot 08, NMR, DMSO.pdf

1. Zou, H.Y., et al, An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms, Cancer Res. 67: 4408-4417 (2007).

2. Bang, Y., et al, Clinical activity of the oral ALK inhibitor PF-02341066 in ALK-positive patients with non-small cell lung cancer (NSCLC), J. Clin. Oncol. 28: 3 (2010).

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