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PCI-32765 (Ibrutinib)
B-cell antigen receptor (BCR) signaling is required for tumor expansion and proliferation. Bruton's Tyrosine Kinase (BTK) is an essential element of the BCR signaling pathway. Containment of BTK blocks BCR signaling and induces apoptosis. PCI-32765 is a potent, selective and orally bioavailable irreversible inhibitor of BTK with IC50 value of 0.5 nM.
Catalog NO: CT-PCI327
Synonym: Ibrutinib
CAS NO: 936563-96-1
Mol. Formula: C25H24N6O2
MW: 440.5
** in vivo Grade Material. Snow-white powder (Pic attached), recrystallized, >99.8% purity, a single isomer (Clinically-Active Enantiomer,100%ee by Chiral HPLC) + A spot-on quantitative microanalysis. Bulk stock!! Prompt.