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PCI-32765 (Ibrutinib)
B-cell antigen receptor (BCR) signaling is required for tumor expansion and proliferation. Bruton's Tyrosine Kinase (BTK) is an essential element of the BCR signaling pathway. Containment of BTK blocks BCR signaling and induces apoptosis. PCI-32765 is a potent, selective and orally bioavailable irreversible inhibitor of BTK with IC50 value of 0.5 nM.
Catalog NO: CT-PCI327
Synonym: Ibrutinib
CAS NO: 936563-96-1
Mol. Formula: C25H24N6O2
MW: 440.5
** Snow-white powder (see attached picture), recrystallized, >99.8% purity, a single isomer (Clinically-Active enantiomer,100% ee by Chiral HPLC) + A perfect quantitative microanalysis. Bulk stock!! Same day shipping from Indianapolis USA.