Palbociclib (PD-0332991) (HCl Salt) - Chemietek

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Home > Kinase Inhibitors > CDK (Cyclin-dependent Kinase) > Palbociclib (PD-0332991) (HCl Salt)

Palbociclib (PD-0332991) (HCl Salt)

Palbociclib (PD-0332991) is an orally bioavailable, potent and highly selective cyclindependent kinase 4 and 6 (CDK 4/6) with IC₅₀ at 11 and 16 nM, respectively.

Catalog NO:	CT-PD2991
Synonym:	PD-0332991
CAS NO:	827022-32-2
Mol. Formula:	C₂₄H₂₉N₇O₂ ∙ HCl
MW:	484.0 (or refer to Certificate of Analysis)

** in vivo Grade Material. A pale yellow crystalline powder, recrystallized (pic attached), >99.5% + impecable 1H-NMR + A Spot-on high-precision quantitative Elemental Analysis. Bulk Stock!!. Prompt.

Pricing and OrderingTechnical Data

QC & Certificates

References

NO	Size	Price	In Stock	Quantity
1	50 mg	$85.00	YES
2	100 mg	$120.00	YES
3	200 mg	$190.00	YES
4	500 mg	$350.00	YES

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Solubility : Soluble in DMSO and water

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : >99.5% (HPLC at 214 and 254 nm)

Original QC Data : HPLC, ¹HNMR

Please Pick Batch NO:

Palbociclib, HCl salt, Lot 09, Certificate of Analysis.pdf
Palbociclib HCl, Lot 09, Visual Appearance (color).pdf

1. Rivadeneira, Dayana B.; Mayhew, Christopher N.; Thangavel, Chellappagounder; Sotillo, Elena; Reed, Christopher A.; Grana, Xavier; Knudsen, Erik S. Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells. Gastroenterology (2010), 138(5), 1920-1930.

2. Dean, J. L.; Thangavel, C.; McClendon, A. K.; Reed, C. A.; Knudsen, E. S. Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure. Oncogene No pp. yet given. CODEN: ONCNES ISSN:0950-9232. AN 2010:612647.

3. Michaud, Karine; Solomon, David A.; Oermann, Eric; Kim, Jung-Sik; Zhong, Wei-Zhu; Prados, Michael D.; Ozawa, Tomoko; James, C. David; Waldman, Todd. Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts. Cancer Research (2010), 70(8), 3228-3238.

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