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Oprozomib (ONX 0912), a tripeptide epoxyketone, is an ORALLY ACTIVE and irreversible inhibitor of 20S proteasome inhibitor targeting primarily chymotrypsin-like activity. It inhibits growth and induces apoptosis in MM (multiple myeloma) cells resistant to conventional and bortezomib therapies. Its anti-MM activity is associated with activation of caspase-8, caspase-9, caspase-3, and poly(ADP) ribose polymerase, as well as inhibition of migration of MM cells and angiogenesis (ref 1).
Catalog NO: CT-OPRO
Synonym: ONX-0912, PR-047
CAS NO: 935888-69-0
Mol. Formula: C25H32N4O7S
MW: 532.6