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Kinase Inhibitors
Activated Factor VII (Factor VIIa)
Arginase Inhibitor
Adenosine Receptor Ligands
Autotaxin Inhibitor
Bcl-2 Protein Inhibitors/Degraders
BCL-6 Protein Inhibitors
CD73 Immune Pathway Inhibitor/Modulator
Cell Cycle Modulators
Cell Metabolism Modulators
Chemotherapy
CoREST-selective Deacetylase (CoreDAC) inhibitors
Cyclin A/B
Degraders (Protein Degraders)
DNA Methyltransferase Inhibtors
DNA Repair Targeted Therapy
DNA/RNA Synthesis Inhibitor/Blocker
Endoplasmic Reticulum Stress Modulator (ERSM)
Epigenetics Resch Products
Estrogen Receptor Modulators
Gamma (γ) Secretase (GS) Inhibitors
Glucocorticoid Receptor Antagonist/Modulator
Glucokinase Activator
Glutaminase Inhibitor
G-Protein-coupled Receptor Ligands
Heat Shock Protein Research Products
Hedgehog Signaling Pathway Modulators
HIF-2α (Hypoxia-inducible Factor 2α)
HIF-1β (ARNT) (Aryl hydrocarbon receptor nuclear translocator).
Hippo Pathway Signaling Inhibitor
HMG-CoA Reductase
Hormone Receptor Modulators
IDO1 (INDOLEAMINE 2,3-DIOXYGENASE 1) Inhibitors
IDH (Isocitrate Dehydrogenase) Inhibitors
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
Immune Activation Agents/Modulators
Immuno/Inflammatory Mediators
Immunoproteasome Inhibitor
Immuno-oncology Modulators
Immunosuppressants/Immunochemotherapy Agents
Isomerase Inhibitor/Modulator
Kinesin Ligand/Modulator
KRAS Pathway
Liver X receptor (LXR) Agonist/Modulator
Metabolic Pathway Modulators
Monocarboxylate Transporter 1 (MCT 1) Inhibitor/Ligand
Monocarboxylate Transporter 4 (MCT 4) Inhibitor
MTH1 (NUDT1, Human MutT Homologue)
Neuroactive Research Products
Notch/Wnt Signaling Pathway
Nuclear Export Protein Inhibitors/Modulators
Other Enzyme Inhibitors/Modulators
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
PARG (Poly (ADP-ribose) Glycohydrolase) Inhibitor
PD-1/PD-L1 Checkpoint Inhibitors
p53–MDM2 Modulators
PCNA (Proliferating Cell Nuclear Antigen)
PDE4 ( Phosphodiesterase Type 4) Inhibitor/Modulators
Peptidylarginine Deiminase (PAD) Inhibitor
Phosphatase Inhibitors/Modulators
PLA2 (Phospholipase A2) Inhibitor
Polymerase Inhibitor/Modulator
PPARG Agonist (Peroxisome Proliferator-activated Receptor Gamma Agomist)
Protease (Peptidase) (Hydrolase) Inhibitors
Reagents for Biological Assays
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
SMAC Mimics and Inhibitors of IAP
Stem Cell Research Products
STING (Stimulator of Interferon Genes) Agonist
SUMO Pathway Modulator
TEAD Inhibitor
Toll-like Receptor Modulators
Ubiquitin / Proteasome System
Wnt Signaling Pathway Modulators
WRN helicase Inhibitor
YAP/TAZ Signaling Inhibitor
Zinc Finger Protein Degrader
Akt/(PKB (Protein Kinase B)
ALK (Anaplastic Lymphoma Kinase)
AMPK (AMP-Activated Protein Kinase)
ASK1 (Apoptosis Signal-regulating Kinase 1)
ATM (Ataxia Telangiectasia Mutated Kinase)
ATR (Ataxia Telangiectasia and Rad3 Related)
Aurora Kinase
Aurora A Kinase Selective
Aurora B Kinase Selective
Aurora C Kinase Selective
AXL (AXL Receptor Tyrosine Kinase)
Bcr-Abl/c-kit/PDGFR/Src
BTK (Bruton's Tyrosine Kinase)
BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)
CDC7 (Cell Division Cycle 7-related Protein Kinase)
CDK (Cyclin-dependent Kinase)
CDK2 Selective
CDK4 Selective
CDK7 Selective
CDK9 Selective
CDK12/CDK13
CHK (Checkpoint Kinase)
CLK (CDC2-like-Kinase)
CLK2 (CDC2-like Kinase 2)
c-Met
DDK (Dbf4-dependent kinase)
DNA-PK (DNA-Dependent Protein Kinase)
EGFR Mutants
EGFR Mutant (HER2 Specific)
EGFR/HER2
EphA (Ephrin type-A Receptor) Kinase
EphB4 (Ephrin Type-B Receptor 4) Kinase
ErbB
Erk (Extracellular signal regulated kinase)
FAK (Focal Adhesion Kinase)
FGFR (Fibroblast Growth Factor Receptor)
FGFR4 Specific
FLT3 (Fms-like Tyrosine Kinase 3)
Glucokinase
IGF-1R
JAK (Janus Kinase)
JAK1 Selective
JAK1/JAK2 Selective
JAK2 Selective
JAK3 Selective
LRRK2
MEK/MAPK
Mps1 (Monopolar Spindle 1)
mTOR
NIK (NF-κB-inducing kinase) Inhibitors
NTRKs (Neurotrophic Tyrosine Receptor Kinases)
P21-Activated Kinases
P70S6K (Ribosomal Protein S6 Kinase)
PDGFR
PDK1
PI3K - p110 Alpha (α) Specific
PI3K - p110 Beta (β) Specific
PI3K - p110 Delta (δ) Specific
PI3K - p110 Gamma (γ) Specific
PI3K - Pan
PI3K/mTOR
PIM
PKC (Protein Kinase C)
PKMYT1
PLK (Polo-like kinase)
PLK1 (Polo-like Kinase 1) Selective
PLK4 (Polo-like Kinase 4) Selective
RAF (Rapidly Accelerated Fibrosarcoma)
RET (Rearranged During Transfection) Kinase
RIP1 (Receptor Interacting Protein 1) Kinase
ROCK (Rho-Associated Protein Kinase)
ROS1 (Proto-oncogene Tyrosine-protein Kinase ROS)
Syk (Spleen Tyrosine Kinase)
TGFβ (Transforming Growth Factor Beta (TGFβ) Receptor) Kinase
TOPK (T–lymphokine-activated killer cell–originated protein kinase)
TRK (Tropomyosin Receptor Kinase) (Tyrosine Receptor Kinase)
TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
VEGFR
WEE1
Factor VIIa inhibitor
Bcl-2 Family Protein Inhibitors
BCL-2 Selective Inhibitors
BCL-XL Protein Degrader
BCL-XL Selective Inhibitors
MCL-1 Selective Inhibitors
CD73 (ecto-5'-nucleotidase) Inhibitor
BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)
CBP/β-catenin Modulators
Cell Cycle/DNA Damage
CDK Inhibitors/Modulators
CDC7 (Cell Division Cycle 7-related Protein Kinase)
CHK (Checkpoint Kinase)
CLK (CDC2-like-Kinase)
Cyclin A/B Modulators
DNA Replication Modulators/Breakers
Endoplasmic Reticulum Stress Modulator (ERSM)
G-Quadruplex Ligand
IMPDH Inhibitor
Kinesin (CENP-E) Inhibitor
KRAS-G12C Inhibitors
KRASG12C (ON) (Tri-complex) Inhibitor
KRAS-G12D Inhibitors
KRAS-PDEδ Interaction Inhibitor
KRAS-SOS1 Inhibitors
Menin-KMT2A/MLL interaction inhibitors
Mps1 (Monopolar Spindle 1)
Notch Signaling Inhibitors
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor
p53-MDM2 Interaction Inhibitor
PARG (Poly (ADP-ribose) Glycohydrolase) Inhibitor.
PCNA (Proliferating Cell Nuclear Antigen)
PRC2 (the catalytic subunit of polycomb repressive complex 2) >
PKMYT1 Kinase Inhibitor
SMAC Mimics and Inhibitors of IAP
Survivin
TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
Tubulin
Wee1
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Mutant Isocitrate Dehydrogenase-1 (IDH1) Inhibitor
Mutant Isocitrate Dehydrogenase-2 (IDH2) Inhibitor
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor
Chemotherapy Agents
ATPases (BRG1/BRM)
BET Family Protein Degraders
BET Family Protein Inhibitors
BET/Bromodomain (BDI and BDII) Selective Inhibitors
BET/BRD4 Degrader
BET/BRD9 Degrader
BET Bromodomain II (BDII) Selective Inhibitors
BET/Domain & Sub-set Selective Inhibitors
CBP/P300 Bromodomain Inhibitor
CoreDAC Inhibitors
DNMT1 (DNA Methyltransferase 1) inhibitor
DOT1L Methyltransferase Inhibitor
EP300/CBP HAT (Histone Acetyltransferases) Inhibitor
EZH1/2 Dual Inhibitors
EZH2 Methyltransferase Inhibitors
EZH2 (Mutant) METHYLTRANSFERASE INHIBITOR
HDAC (histone deacetylase) Inhibitors
HDAC1-Specific Inhibitors
HDAC3-Specific Inhibitors
HDAC6-Specific Inhibitors
Lysine specific demethylase 1 (LSD1) Inhibitor
Menin-KMT2A/MLL interaction inhibitors
PRC2 (the catalytic subunit of polycomb repressive complex 2)
PRMT5 (Protein Arginine Methyltransferase 5) Inhibitors/Modulators
PRMTs (Type I) Inhibitors/Modulators
Adenosine Receptor Ligands
Angiotensin II receptor (AT1)
Endothelin receptor antagonist (type A specific)
Heat Shock Proteins HSP90 Inhibitors
Hedgehog Signaling Pathway Inhibitors
HMG-CoA reductase inhibitor
Androgen receptor
Glucocorticoid Receptor
RXRs (retinoid X receptors)
Mutant-IDH1 Inhibitor
Mutant-IDH2 Inhibitor
IMPDH Inhibitor
Liver X receptor (LXR) Agonist/Modulator
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
STING (STIMULATOR OF INTERFERON GENES) AGONIST
Toll-like Receptor Agonist
Anti-angiogenesis
Anti-fibrosis
Anti-inflammatory
Arginase Inhibitor
Autotaxin Inhibitors
PLA2 Inhibitors
Prostanoid ligand
RIP1 (RECEPTOR INTERACTING PROTEIN 1) KINASE
TGFβ Kinase Inhibitor
Adenosine 2A Receptor Antagonist
Arginase Inhibitor
CD73 (ecto-5'-nucleotidase) Inhibitor
CBP/β-catenin Modulators
CoreDAC Inhibitors
IDO1 (Indoleamine 2,3-dioxygenase 1) Inhibitor
Zinc Finger Protein Degrader
Immunoproteasome Inhibitor
Liver X receptor (LXR) Agonist/Modulator
mTOR inhibitors
PD-1/PD-L1 CHECKPOINT INHIBITORS
PI3Kγ (GAMMA) Specific Inhibitors
PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
SHP2 Phosphatase Inhibitor
STING (Stimulator of Interferon Genes) Agonist
SUMOylation Inhibitor
TGFβ Kinase Inhibitor
Toll-like Receptor Modulators
Topoisomerase I
Topoisomerase II
Kinesin (CENP-E) Inhibitor
G12C Mutant Inhibitors
G12D Degrader
G12D Mutant Inhibitors
G12V Mutant Inhibitors
KRAS-PDEδ Interaction Inhibitor
Pan-KRAS Inhibitors
SOS1 Inhibitors
Tri-complex KRAS inhibitors
Tri-complex KRAS G12C (ON) Inhibitor
Tri-complex KRAS-G12CV (ON) Inhibitor
Arginase Inhibitor
Glutaminase Inhibitor
IDH (Isocitrate Dehydrogenase) Inhibitors
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
MAT2A Inhibitor
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Monocarboxylate Transporter 4 (MCT 4)
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
MTH1
Activator of NAMPT (Nicotinamide PphosphoribosylTransferase)
Neuroactive/BBB Penetrant
Orexin Receptor Antagonists
SDAM (Serotonin-Dopamine Activity Modulator)
TRK (Tropomyosin Receptor Kinase)(Tyrosine Receptor Kinase) Inhibitor
CBP/β-catenin Modulators
Gamma (γ) Secretase (GS) Inhibitors
Notch Signaling Inhibitors
CRM1 (exportin 1) Inhibitor(s)
HCV Protease Inhibitor
HIV-1 integrase Inhibitor
Oxidoreductase Inhibitor
P-p68 (Phosphorylated-p68 RNA Helicase) Inhibitor
Thymidylate synthase inhibitor
WRN Helicase Inhibitor
p53–MDM2 Interaction Inhibitor
p53 Reactivator
PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
SHP2 Phosphatase Inhibitor
Wip1 Phosphatase Inhibitor
PARP (Poly (ADP-ribose) polymerase)
Autotaxin
Caspase-1
Cathepsin K
Dipeptidyl Peptidase I (DPP1) (Cathepsin C)
Glycoside Hydrolase
Neprilysin (MME)
PDE4 ( phosphodiesterase type 4)
PLA2 Inhibitors
Stem cell research
NADD8-Activating Enzyme Inhibtor
Proteasome Inhibitor
SUMOylation Inhibitor
Ubiquitin-Activating Enzyme Inhibitor
USP1 (Ubiquitin Specific Protease 1)
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New Products
Featured Products
Kinase Inhibitors
Activated Factor VII (Factor VIIa)
Arginase Inhibitor
Adenosine Receptor Ligands
Autotaxin Inhibitor
Bcl-2 Protein Inhibitors/Degraders
BCL-6 Protein Inhibitors
CD73 Immune Pathway Inhibitor/Modulator
Cell Cycle Modulators
Cell Metabolism Modulators
Chemotherapy
CoREST-selective Deacetylase (CoreDAC) inhibitors
Cyclin A/B
Degraders (Protein Degraders)
DNA Methyltransferase Inhibtors
DNA Repair Targeted Therapy
DNA/RNA Synthesis Inhibitor/Blocker
Endoplasmic Reticulum Stress Modulator (ERSM)
Epigenetics Resch Products
Estrogen Receptor Modulators
Gamma (γ) Secretase (GS) Inhibitors
Glucocorticoid Receptor Antagonist/Modulator
Glucokinase Activator
Glutaminase Inhibitor
G-Protein-coupled Receptor Ligands
Heat Shock Protein Research Products
Hedgehog Signaling Pathway Modulators
HIF-2α (Hypoxia-inducible Factor 2α)
HIF-1β (ARNT) (Aryl hydrocarbon receptor nuclear translocator).
Hippo Pathway Signaling Inhibitor
HMG-CoA Reductase
Hormone Receptor Modulators
IDO1 (INDOLEAMINE 2,3-DIOXYGENASE 1) Inhibitors
IDH (Isocitrate Dehydrogenase) Inhibitors
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
Immune Activation Agents/Modulators
Immuno/Inflammatory Mediators
Immunoproteasome Inhibitor
Immuno-oncology Modulators
Immunosuppressants/Immunochemotherapy Agents
Isomerase Inhibitor/Modulator
Kinesin Ligand/Modulator
KRAS Pathway
Liver X receptor (LXR) Agonist/Modulator
Metabolic Pathway Modulators
Monocarboxylate Transporter 1 (MCT 1) Inhibitor/Ligand
Monocarboxylate Transporter 4 (MCT 4) Inhibitor
MTH1 (NUDT1, Human MutT Homologue)
Neuroactive Research Products
Notch/Wnt Signaling Pathway
Nuclear Export Protein Inhibitors/Modulators
Other Enzyme Inhibitors/Modulators
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
PARG (Poly (ADP-ribose) Glycohydrolase) Inhibitor
PD-1/PD-L1 Checkpoint Inhibitors
p53–MDM2 Modulators
PCNA (Proliferating Cell Nuclear Antigen)
PDE4 ( Phosphodiesterase Type 4) Inhibitor/Modulators
Peptidylarginine Deiminase (PAD) Inhibitor
Phosphatase Inhibitors/Modulators
PLA2 (Phospholipase A2) Inhibitor
Polymerase Inhibitor/Modulator
PPARG Agonist (Peroxisome Proliferator-activated Receptor Gamma Agomist)
Protease (Peptidase) (Hydrolase) Inhibitors
Reagents for Biological Assays
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
SMAC Mimics and Inhibitors of IAP
Stem Cell Research Products
STING (Stimulator of Interferon Genes) Agonist
SUMO Pathway Modulator
TEAD Inhibitor
Toll-like Receptor Modulators
Ubiquitin / Proteasome System
Wnt Signaling Pathway Modulators
WRN helicase Inhibitor
YAP/TAZ Signaling Inhibitor
Zinc Finger Protein Degrader
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Kinase Inhibitors
Akt/(PKB (Protein Kinase B)
ALK (Anaplastic Lymphoma Kinase)
AMPK (AMP-Activated Protein Kinase)
ASK1 (Apoptosis Signal-regulating Kinase 1)
ATM (Ataxia Telangiectasia Mutated Kinase)
ATR (Ataxia Telangiectasia and Rad3 Related)
Aurora Kinase
Aurora A Kinase Selective
Aurora B Kinase Selective
Aurora C Kinase Selective
AXL (AXL Receptor Tyrosine Kinase)
Bcr-Abl/c-kit/PDGFR/Src
BTK (Bruton's Tyrosine Kinase)
BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)
CDC7 (Cell Division Cycle 7-related Protein Kinase)
CDK (Cyclin-dependent Kinase)
CDK2 Selective
CDK4 Selective
CDK7 Selective
CDK9 Selective
CDK12/CDK13
CHK (Checkpoint Kinase)
CLK (CDC2-like-Kinase)
CLK2 (CDC2-like Kinase 2)
c-Met
DDK (Dbf4-dependent kinase)
DNA-PK (DNA-Dependent Protein Kinase)
EGFR Mutants
EGFR Mutant (HER2 Specific)
EGFR/HER2
EphA (Ephrin type-A Receptor) Kinase
EphB4 (Ephrin Type-B Receptor 4) Kinase
ErbB
Erk (Extracellular signal regulated kinase)
FAK (Focal Adhesion Kinase)
FGFR (Fibroblast Growth Factor Receptor)
FGFR4 Specific
FLT3 (Fms-like Tyrosine Kinase 3)
Glucokinase
IGF-1R
JAK (Janus Kinase)
JAK1 Selective
JAK1/JAK2 Selective
JAK2 Selective
JAK3 Selective
LRRK2
MEK/MAPK
Mps1 (Monopolar Spindle 1)
mTOR
NIK (NF-κB-inducing kinase) Inhibitors
NTRKs (Neurotrophic Tyrosine Receptor Kinases)
P21-Activated Kinases
P70S6K (Ribosomal Protein S6 Kinase)
PDGFR
PDK1
PI3K - p110 Alpha (α) Specific
PI3K - p110 Beta (β) Specific
PI3K - p110 Delta (δ) Specific
PI3K - p110 Gamma (γ) Specific
PI3K - Pan
PI3K/mTOR
PIM
PKC (Protein Kinase C)
PKMYT1
PLK (Polo-like kinase)
PLK1 (Polo-like Kinase 1) Selective
PLK4 (Polo-like Kinase 4) Selective
RAF (Rapidly Accelerated Fibrosarcoma)
RET (Rearranged During Transfection) Kinase
RIP1 (Receptor Interacting Protein 1) Kinase
ROCK (Rho-Associated Protein Kinase)
ROS1 (Proto-oncogene Tyrosine-protein Kinase ROS)
Syk (Spleen Tyrosine Kinase)
TGFβ (Transforming Growth Factor Beta (TGFβ) Receptor) Kinase
TOPK (T–lymphokine-activated killer cell–originated protein kinase)
TRK (Tropomyosin Receptor Kinase) (Tyrosine Receptor Kinase)
TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
VEGFR
WEE1
Activated Factor VII (Factor VIIa)
Factor VIIa inhibitor
Arginase Inhibitor
Adenosine Receptor Ligands
Autotaxin Inhibitor
Bcl-2 Protein Inhibitors/Degraders
Bcl-2 Family Protein Inhibitors
BCL-2 Selective Inhibitors
BCL-XL Protein Degrader
BCL-XL Selective Inhibitors
MCL-1 Selective Inhibitors
BCL-6 Protein Inhibitors
CD73 Immune Pathway Inhibitor/Modulator
CD73 (ecto-5'-nucleotidase) Inhibitor
Cell Cycle Modulators
BUB1 (Budding Uninhibited by Benzimidazoles 1)(Mitotic checkpoint serine/threonine-protein kinase)
CBP/β-catenin Modulators
Cell Cycle/DNA Damage
CDK Inhibitors/Modulators
CDC7 (Cell Division Cycle 7-related Protein Kinase)
CHK (Checkpoint Kinase)
CLK (CDC2-like-Kinase)
Cyclin A/B Modulators
DNA Replication Modulators/Breakers
Endoplasmic Reticulum Stress Modulator (ERSM)
G-Quadruplex Ligand
IMPDH Inhibitor
Kinesin (CENP-E) Inhibitor
KRAS-G12C Inhibitors
KRASG12C (ON) (Tri-complex) Inhibitor
KRAS-G12D Inhibitors
KRAS-PDEδ Interaction Inhibitor
KRAS-SOS1 Inhibitors
Menin-KMT2A/MLL interaction inhibitors
Mps1 (Monopolar Spindle 1)
Notch Signaling Inhibitors
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor
p53-MDM2 Interaction Inhibitor
PARG (Poly (ADP-ribose) Glycohydrolase) Inhibitor.
PCNA (Proliferating Cell Nuclear Antigen)
PRC2 (the catalytic subunit of polycomb repressive complex 2) >
PKMYT1 Kinase Inhibitor
SMAC Mimics and Inhibitors of IAP
Survivin
TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1))
Tubulin
Wee1
Cell Metabolism Modulators
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Mutant Isocitrate Dehydrogenase-1 (IDH1) Inhibitor
Mutant Isocitrate Dehydrogenase-2 (IDH2) Inhibitor
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator/Inhibitor
Chemotherapy
Chemotherapy Agents
CoREST-selective Deacetylase (CoreDAC) inhibitors
Cyclin A/B
Degraders (Protein Degraders)
DNA Methyltransferase Inhibtors
DNA Repair Targeted Therapy
DNA/RNA Synthesis Inhibitor/Blocker
Endoplasmic Reticulum Stress Modulator (ERSM)
Epigenetics Resch Products
ATPases (BRG1/BRM)
BET Family Protein Degraders
BET Family Protein Inhibitors
BET/Bromodomain (BDI and BDII) Selective Inhibitors
BET/BRD4 Degrader
BET/BRD9 Degrader
BET Bromodomain II (BDII) Selective Inhibitors
BET/Domain & Sub-set Selective Inhibitors
CBP/P300 Bromodomain Inhibitor
CoreDAC Inhibitors
DNMT1 (DNA Methyltransferase 1) inhibitor
DOT1L Methyltransferase Inhibitor
EP300/CBP HAT (Histone Acetyltransferases) Inhibitor
EZH1/2 Dual Inhibitors
EZH2 Methyltransferase Inhibitors
EZH2 (Mutant) METHYLTRANSFERASE INHIBITOR
HDAC (histone deacetylase) Inhibitors
HDAC1-Specific Inhibitors
HDAC3-Specific Inhibitors
HDAC6-Specific Inhibitors
Lysine specific demethylase 1 (LSD1) Inhibitor
Menin-KMT2A/MLL interaction inhibitors
PRC2 (the catalytic subunit of polycomb repressive complex 2)
PRMT5 (Protein Arginine Methyltransferase 5) Inhibitors/Modulators
PRMTs (Type I) Inhibitors/Modulators
Estrogen Receptor Modulators
Gamma (γ) Secretase (GS) Inhibitors
Glucocorticoid Receptor Antagonist/Modulator
Glucokinase Activator
Glutaminase Inhibitor
G-Protein-coupled Receptor Ligands
Adenosine Receptor Ligands
Angiotensin II receptor (AT1)
Endothelin receptor antagonist (type A specific)
Heat Shock Protein Research Products
Heat Shock Proteins HSP90 Inhibitors
Hedgehog Signaling Pathway Modulators
Hedgehog Signaling Pathway Inhibitors
HIF-2α (Hypoxia-inducible Factor 2α)
HIF-1β (ARNT) (Aryl hydrocarbon receptor nuclear translocator).
Hippo Pathway Signaling Inhibitor
HMG-CoA Reductase
HMG-CoA reductase inhibitor
Hormone Receptor Modulators
Androgen receptor
Glucocorticoid Receptor
RXRs (retinoid X receptors)
IDO1 (INDOLEAMINE 2,3-DIOXYGENASE 1) Inhibitors
IDH (Isocitrate Dehydrogenase) Inhibitors
Mutant-IDH1 Inhibitor
Mutant-IDH2 Inhibitor
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
IMPDH Inhibitor
Immune Activation Agents/Modulators
Liver X receptor (LXR) Agonist/Modulator
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
STING (STIMULATOR OF INTERFERON GENES) AGONIST
Toll-like Receptor Agonist
Immuno/Inflammatory Mediators
Anti-angiogenesis
Anti-fibrosis
Anti-inflammatory
Arginase Inhibitor
Autotaxin Inhibitors
PLA2 Inhibitors
Prostanoid ligand
RIP1 (RECEPTOR INTERACTING PROTEIN 1) KINASE
TGFβ Kinase Inhibitor
Immunoproteasome Inhibitor
Immuno-oncology Modulators
Adenosine 2A Receptor Antagonist
Arginase Inhibitor
CD73 (ecto-5'-nucleotidase) Inhibitor
CBP/β-catenin Modulators
CoreDAC Inhibitors
IDO1 (Indoleamine 2,3-dioxygenase 1) Inhibitor
Zinc Finger Protein Degrader
Immunoproteasome Inhibitor
Liver X receptor (LXR) Agonist/Modulator
mTOR inhibitors
PD-1/PD-L1 CHECKPOINT INHIBITORS
PI3Kγ (GAMMA) Specific Inhibitors
PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1) Inhibitors
RORγ (Retinoic Acid-related Orphan Receptor gamma (γ )) Agonist
SHP2 Phosphatase Inhibitor
STING (Stimulator of Interferon Genes) Agonist
SUMOylation Inhibitor
TGFβ Kinase Inhibitor
Toll-like Receptor Modulators
Immunosuppressants/Immunochemotherapy Agents
Isomerase Inhibitor/Modulator
Topoisomerase I
Topoisomerase II
Kinesin Ligand/Modulator
Kinesin (CENP-E) Inhibitor
KRAS Pathway
G12C Mutant Inhibitors
G12D Degrader
G12D Mutant Inhibitors
G12V Mutant Inhibitors
KRAS-PDEδ Interaction Inhibitor
Pan-KRAS Inhibitors
SOS1 Inhibitors
Tri-complex KRAS inhibitors
Tri-complex KRAS G12C (ON) Inhibitor
Tri-complex KRAS-G12CV (ON) Inhibitor
Liver X receptor (LXR) Agonist/Modulator
Metabolic Pathway Modulators
Arginase Inhibitor
Glutaminase Inhibitor
IDH (Isocitrate Dehydrogenase) Inhibitors
IMPDH (Inosine Monosphosphate Dehydrogenase) Inhibitor
MAT2A Inhibitor
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Monocarboxylate Transporter 4 (MCT 4)
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
Monocarboxylate Transporter 1 (MCT 1) Inhibitor/Ligand
Monocarboxylate Transporter 1 (MCT 1) Inhibitor
Monocarboxylate Transporter 4 (MCT 4) Inhibitor
MTH1 (NUDT1, Human MutT Homologue)
MTH1
Neuroactive Research Products
Activator of NAMPT (Nicotinamide PphosphoribosylTransferase)
Neuroactive/BBB Penetrant
Orexin Receptor Antagonists
SDAM (Serotonin-Dopamine Activity Modulator)
TRK (Tropomyosin Receptor Kinase)(Tyrosine Receptor Kinase) Inhibitor
Notch/Wnt Signaling Pathway
CBP/β-catenin Modulators
Gamma (γ) Secretase (GS) Inhibitors
Notch Signaling Inhibitors
Nuclear Export Protein Inhibitors/Modulators
CRM1 (exportin 1) Inhibitor(s)
Other Enzyme Inhibitors/Modulators
HCV Protease Inhibitor
HIV-1 integrase Inhibitor
Oxidoreductase Inhibitor
P-p68 (Phosphorylated-p68 RNA Helicase) Inhibitor
Thymidylate synthase inhibitor
WRN Helicase Inhibitor
OXPHOS (Mitochondrial Oxidative Phosphorylation of Complex I) Modulator
PARG (Poly (ADP-ribose) Glycohydrolase) Inhibitor
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NVP-IAG933
NVP-IAG933
NVP-IAG933 (IAG933) is a selective and orally efficacious YAP1/WWTR1(TAZ)-pan TEAD protein-protein interaction inhibitor, the first class of small molecules potently disrupting the YAP-TEAD interaction by direct competition (refs. 1, 2).
Catalog NO:
CT-IAG933
Synonym:
IAG933, IAG-933
CAS NO:
2714434-21-4
Mol. Formula:
C27H26ClF2N3O4 ·1/2H
2
O
MW:
539.0 (or refer to the Certificate of Analysis, batch-specific)
** in vivo Quality Material. >99.5% Pure by Achiral and Chiral HPLCs (attached). Hemihydrate, Validated by a spot-on Elemental Analysis. Validated Absolute Configuration (Data Available). Bulk stock (Discounted price for 0.5, 1G, 2G, …). Same Day Shipping.
Pricing and Ordering
Technical Data
QC & Certificates
References
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Size
Price
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Quantity
1
10 mg
$160.00
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2
50 mg
$480.00
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Solubility :
Refer to Certificate of Analysis
Storage :
Refer to Certificate of Analysis
Purity :
>99% by Achiral and Chiral HPLCs
Original QC Data :
Achiral and Chiral HPLCs, MS, NMR, and Quantitative Elemental Analysis Report
Please Pick Batch NO:
4
IAG-933 (NVP-IAG933) Lot 04 Certificate of Analysis.pdf
IAG-933 Lot 04 Visual Appearance.pdf
C_K, IAG-933, Lot 04, Achiral HPLC.pdf
C_K, IAG-933, Lot 04, Chiral HPLC.pdf
C_K, IAG-933, Lot 04, NMR, DMSO 2.pdf
1. Chapeau, E.A., Sansregret, L., Galli, G.G. et al., Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers, Nat Cancer Volume 5, pages1102–1120 (2024). https://doi.org/10.1038/s43018-024-00754-9
2. M. Vögtle, et al., Discovery of Clinical Candidate IAG933, a Potent YAP-TEAD PPI Disrupter, J. Med. Chem. (2026) 69 (7): 7782–7816
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