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Home > Cell Cycle Modulators > p53-MDM2 Interaction Inhibitor > NVP-CGM097 (Free Base)

NVP-CGM097 (Free Base)

NVP-CGM097 (CGM-097) is a potent and selective MDM2 inhibitor. Optically pure (S-Enantiomer) NVP-CGM097 binds to the p53 binding-site of the Human MDM2 protein with an IC50 value of 1.7 nM, highly selective against other protein-protein interactions such as p53:MDM4 (>1000-fold selectivity), Ras:Raf (3000-fold selectivity), and showing no signiﬁcant activity against Bcl-2:Bak, Bcl-2:Bad, Mcl-1:Bak, Mcl-1:NOXA, XIAP:BIR3, and c-IAP:BIR3 protein−protein interactions. It inhibits the p53:MDM2 interaction in cells, leading to p53 nuclear translocation that results in cell growth inhibition in a p53-dependent manner (ref. 1). Exhibit excellent in vivo pharmacological properties. It is currently in clinical evaluations in p53wt tumors (ref. 1).

Catalog NO:	CT-CGMFB
Synonym:	CGM097
CAS NO:	1313363-54-0
Mol. Formula:	C₃₈H₄₇ClN₄O₄·1/2H₂O
MW:	668.3

** in vivo Quality Material. >99.5% pure by Achiral and Chiral HPLCs, Salt-Free, Hemihydrate, validated by Quantitative Elemental Analysis. In stock (Grams. Pls ask for Bulk quote). Prompt from Indianapolis.

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NO	Size	Price	In Stock	Quantity
1	5 mg	$120.00	YES
2	10 mg	$180.00	YES
3	50 mg	$550.00	YES

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Solubility : refer to Certificate of Analysis

Storage : refer to Certificate of Analysis

Purity : >99% by Achiral and Chiral HPLCs

Original QC Data : Achiral and Chiral HPLCs,MS, 1H-NMR, and Elemental Analysis Report

Please Pick Batch NO:

NVP-CGM097, Free Base, Lot 05, Certificate of Analysis,.pdf

1. 3. P. Holzer, et al, Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase1 Clinical Trials in p53wt Tumors, J. Med. Chem. 2015, 58, 6348−6358

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