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NVP-CGM097 (Free Base)
NVP-CGM097 (CGM-097) is a potent and selective MDM2 inhibitor. Optically pure (S-Enantiomer) NVP-CGM097 binds to the p53 binding-site of the Human MDM2 protein with an IC50 value of 1.7 nM, highly selective against other protein-protein interactions such as p53:MDM4 (>1000-fold selectivity), Ras:Raf (3000-fold selectivity), and showing no significant activity against Bcl-2:Bak, Bcl-2:Bad, Mcl-1:Bak, Mcl-1:NOXA, XIAP:BIR3, and c-IAP:BIR3 protein−protein interactions. It inhibits the p53:MDM2 interaction in cells, leading to p53 nuclear translocation that results in cell growth inhibition in a p53-dependent manner (ref. 1). Exhibit excellent in vivo pharmacological properties. It is currently in clinical evaluations in p53wt tumors (ref. 1).
Catalog NO: CT-CGMFB
Synonym: CGM097
CAS NO: 1313363-54-0
Mol. Formula: C38H47ClN4O4·1/2H2O
MW: 668.3
** in vivo Quality Material. >99.5% pure by Achiral and Chiral HPLCs, Salt-Free, Hemihydrate, validated by Quantitative Elemental Analysis. In stock (Grams. Pls ask for Bulk quote). Prompt from Indianapolis.