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NVP-BHG712 (BHG-712)
NVP-BHG712 is an orally bioavailable selective inhibitor of EphB4 kinase with IC50 of 25 nM in cellular assays; Displaying selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3. It inhibits EphB4 autophosphorylation in transiently transfected HEK 293 cells. It also inhibits VEGF-induced angiogenesis in vivo thought to inhibit EphB4 forward signaling which appears to be an important mediator of VEGF induced angiogenesis (ref 1).
Catalog NO: CT-BHG712
Synonym: BHG712, BHG-712
CAS NO: 940310-85-0
Mol. Formula: C26H20F3N7O
MW: 503.5 (or refer to Certificate of Analysis, batch-specific)
** in vivo grade material, 99.5% Pure. Buyer Beware: A wrong isomer with low activity is being offered in marketplace by many other vendors for years. Chemietek guarantees the correct compound. In stock, same day shipping.