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Home > Kinase Inhibitors > PI3K/mTOR > NVP-BEZ235

NVP-BEZ235

An Orally active dual inhibitor of the Phosphatidylinositol-3-kinase (PI3K) and the downstream mammalian target of rapamycin (mTOR), displaying potent in vivo antitumor activity.

Catalog NO:	CT-BEZ
Synonym:	BEZ235
CAS NO:	915019-65-7
Mol. Formula:	C₃₀H₂₃N₅O
MW:	469.55

** Trouble in solubility? * Our product BEZ235 is well-dissolved in 1 Vol of N-methyl-2-pyrrolidone (NMP) and 9 Vol of PEG300, a vehicle for animal study (Ref. 2).

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NO	Size	Price	In Stock	Quantity
1	5 mg	$120.00	YES

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Solubility : Soluble in DMSO

Storage : Store at 0°C (short term), -20°C (long term), desiccated

Purity : 99% (HPLC at 214 and 254 nm)

Original QC Data : ¹HNMR, HPLC and MS

Please Pick Batch NO:

NVP-BEZ235, lot 01H, COA

1. Maira, SM., et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther, 2008, 7(7), 1851–1863;

2. J. A. Engelman, et al, Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers, Nature Medicine, 14, 1351-1356 (2008)

*Our product NVP-BEZ235 is readily soluble at ROOM TEMPERATURE in N-methyl-2-pyrrolidone (NMP), and DMSO at a concentration at least 10mg/ml.

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