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Skip Navigation LinksHome > Kinase Inhibitors > PLK (Polo-like kinase) > NMS1286937 (NMS-P937)
NMS1286937 (NMS-P937)
NMS1286937 (NMS-P937) is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. NMS-1286937 selectively and effectively inhibits PLK1 (with IC50 at low nM), inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. It is currently in clinical trials.
Catalog NO: CT-NMS128
Synonym: NMS-P937
CAS NO: 1034616-18-6
Mol. Formula: C24H27F3N8O3
MW: 532.5
** in vivo grade. An off-white crystalline solid (picture attached), re-crystallized, clean (>99.5% by HPLC), + impeccable 1H-NMR, coming with a spot-on quantitative elemental analysis. Bulk stock!!! Ship within 1 day.