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Home > KRAS Pathway Inhibitors > G12C Mutant Inhibitors > MRTX1257 (MRTX-1257)

MRTX1257 (MRTX-1257)

MRTX1257 (MRTX-1257) is an orally available, potent, selective, and irreversible covalent inhibitor of KRAS G12C. It inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC₅₀ of 0.9 nM, and is highly selective for the Cys12 of KRAS G12C in NCI-H358 cells over other cysteines; Demonstrates robust target engagement in vivo; Exhibits rapid and sustained efficacy against MIA PaCa-2 Xenocrafts, in which, at 100 mg/kg daily dose, leads to complete responses that are maintained >70 days after cessation of treatment. (ref 1).

Catalog NO:	CT-MRTX1257
Synonym:	MRTX1257
CAS NO:	2206736-04-9
Mol. Formula:	C₃₃H₃₉N₇O₂
MW:	565.7 (or refer to Certificate of Analysis, batch-specific)

** 99.9-100% by achiral and chiral HPLCs (attached). in vivo Quality Material. Hemihydrate, validated by a spot-on Quantitative Elemental Analysis, validated Cellular Potency (IC₅₀ = 1 nM)*. Bulk!! Prompt from Indianapolis.

Pricing and OrderingTechnical Data

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NO	Size	Price	In Stock	Quantity
1	10 mg	$120.00	YES
2	50 mg	$350.00	YES
3	100 mg	$550.00	YES
4	200 mg	$950.00	YES

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Toll-free: 1-877-343-6578 (US and Canada only)

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Solubility : Refer to Certificate of Analysis

Storage : Refer to Certificate of Analysis

Purity : >99.5% by Achiral and Chiral HPLCs

Original QC Data : Achiral and Chiral HPLCs, MS, NMR, and Quantitative Elemental Analysis Report

Please Pick Batch NO:

MRTX1257 (MRTX-1257), Lot 01, Certificate of Analysis.pdf
MRTX-1257, Lot 01, Visual Appearance.pdf

* to inhibit H358 cell proliferation/growth

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