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MRTX1133 is a first-in-class, noncovalent, selective & reversible inhibitor of KRASG12D mutant in both active and inactive states. Demonstrates selective inhibition of cell viability of KRASG12D mutant, but not KRAS wild-type, tumor cells. Displays sustained dose-dependent inhibition of KRAS-dependent signaling in mouse tumor models (ref 1, 2).
Catalog NO: CT-MTX1133
CAS NO: 2621928-55-8
Mol. Formula: C33H31F3N6O2
MW: 600.6
** in vivo Quality Material. >99% Pure by Achiral and Chiral HPLCs (attached). Validated Activity against KRASG12D Mutant. In stock, prompt. Please ask quote for other quantities (100, 200, 500MG, 1G, 2G, and, more, …)