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MLN7243 (TAK-243, AOB 87172)
MLN7243 (TAK-243) is a cell permeable small molecule inhibitor targeting ubiquitin-activating enzymes (UAE, also known as E1 enzymes). The enzymes, found more active in cancer cells than in normal, healthy cells, catalyze the first step in ubiquitination reaction, targeting a protein for degradation via Proteasome. This covalent attachment of ubiquitin or ubiquitin-like proteins to targeted proteins is a major mechanism for regulating protein function in eukaryotic organisms. Inhibition of the enzyme prevents both protein ubiquitination and subsequent ubiquitin-mediated proteasomal degradation, resulting in an excess of proteins in the cells that may lead to endoplasmic reticulum (ER) stress-mediated apoptosis, thus inhibit tumor (cancer) cell proliferation and survival. MLN7243 is the first-in-class inhibitor specifically targeting this class of enzyme to be studied clinically.
Catalog NO: CT-M7243
Synonym: TAK-243, AOB 87172
CAS NO: 1450833-55-2
Mol. Formula: C19H20F3N5O5S2
MW: 519.5
** White crystalline powder (See attached picture), 100% optically (stereomerically) pure by Chiral HPLC, + a spot-on high-precision quantitative elemental analysis, a testament to superior quality. Bulk Stock! Same day shipping.